Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer.

IF 7.8 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2024-03-30 DOI:10.1038/s41522-024-00506-8

Aitor Blanco-Míguez, Sara Carloni, Cindy Cardenas, Carola Conca Dioguardi, Luca Lambroia, Giovanni Capretti, Gennaro Nappo, Alessandro Fugazza, Antonio Capogreco, Federica Armanini, Francesco Asnicar, Leonard Dubois, Davide Golzato, Paolo Manghi, Federica Pinto, Cristina Scuderi, Erminia Casari, Marco Montorsi, Andrea Anderloni, Maria Rescigno, Alessandro Repici, Alessandro Zerbi, Clelia Peano, Sabrina Tamburini, Roberto Rusconi, Nicola Segata

引用次数: 0

Abstract

Malignant bile duct obstruction is typically treated by biliary stenting, which however increases the risk of bacterial infections. Here, we analyzed the microbial content of the biliary stents from 56 patients finding widespread microbial colonization. Seventeen of 36 prevalent stent species are common oral microbiome members, associate with disease conditions when present in the gut, and include dozens of biofilm- and antimicrobial resistance-related genes. This work provides an overview of the microbial communities populating the stents.

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因癌症接受胰腺切除术的患者体内与胆道支架相关的微生物组成。

恶性胆管梗阻通常采用胆道支架治疗，但这会增加细菌感染的风险。在此，我们分析了 56 名患者胆道支架中的微生物含量，发现了广泛的微生物定植。在 36 种普遍存在的支架物种中，有 17 种是常见的口腔微生物群成员，在肠道中存在时与疾病相关，并包括数十种生物膜和抗菌药耐药性相关基因。这项研究提供了支架微生物群落的概况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.