Probing pharmaceutically important amino acids L-isoleucine and L-tyrosine Solubilities: Unraveling the solvation thermodynamics in diverse mixed solvent systems

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biophysical chemistry Pub Date : 2024-03-27 DOI:10.1016/j.bpc.2024.107229

Jit Chakraborty , Kalachand Mahali , A.M.A. Henaish , Jahangeer Ahmed , Saad M. Alshehri , Sanjay Roy

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Abstract

The study specifically investigates the solubilities of L-isoleucine and L-tyrosine in water-mixed solvent systems (DMF, DMSO, and ACN), exploring the behaviour of amino acids in complex environments. The experimental methods prioritize meticulous solvent purification to ensure reliable results. The work explores solubility data, uncovering temperature-dependent trends and intricate interactions influencing solubility in the chosen mixed solvent systems. The study emphasizes the impact of thermodynamic properties, solvent-solvent interactions, and amino acid structure on solubility patterns. The broader implications highlight the relevance of understanding amino acid behaviour in diverse solvent environments, offering potential applications in cosmetics and pharmaceutical industries. The distinct solubility patterns contribute valuable insights, enhancing on the understanding of the solution stability and interactions of L-isoleucine and L-tyrosine in different solvent systems. In conclusion, work suggests the enhanced utilization of L-isoleucine and L-tyrosine in various industries, driven by a profound understanding of their solubility in mixed solvent systems. The research expands our knowledge of amino acid behaviour, paving the way for advancements in industries relying on protein-based products and technologies.

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探索具有重要药用价值的氨基酸 L-异亮氨酸和 L-酪氨酸的溶解度：揭示不同混合溶剂体系中的溶解热力学

该研究特别考察了 L-异亮氨酸和 L-酪氨酸在水混合溶剂系统（DMF、DMSO 和 ACN）中的溶解度，探索氨基酸在复杂环境中的行为。实验方法优先考虑细致的溶剂纯化，以确保结果可靠。这项研究探索了溶解度数据，揭示了所选混合溶剂体系中影响溶解度的温度依赖性趋势和错综复杂的相互作用。研究强调了热力学特性、溶剂-溶剂相互作用以及氨基酸结构对溶解度模式的影响。研究的广泛意义突出表明，了解氨基酸在不同溶剂环境中的行为与化妆品和制药行业的潜在应用息息相关。不同的溶解度模式有助于深入了解 L- 异亮氨酸和 L- 酪氨酸在不同溶剂体系中的溶液稳定性和相互作用。总之，研究结果表明，通过深入了解 L-异亮氨酸和 L-酪氨酸在混合溶剂体系中的溶解度，可以提高它们在各行各业中的利用率。这项研究拓展了我们对氨基酸行为的认识，为依赖蛋白质产品和技术的行业的进步铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biophysical chemistry 生物-生化与分子生物学

CiteScore

6.10

自引率

10.50%

发文量

121

审稿时长

20 days

期刊介绍： Biophysical Chemistry publishes original work and reviews in the areas of chemistry and physics directly impacting biological phenomena. Quantitative analysis of the properties of biological macromolecules, biologically active molecules, macromolecular assemblies and cell components in terms of kinetics, thermodynamics, spatio-temporal organization, NMR and X-ray structural biology, as well as single-molecule detection represent a major focus of the journal. Theoretical and computational treatments of biomacromolecular systems, macromolecular interactions, regulatory control and systems biology are also of interest to the journal.