Endoscopic duodenal mucosa ablation: the future of diabetes treatment?

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2024-07-01 Epub Date: 2024-03-29 DOI:10.1016/j.molmed.2024.03.003

Giovanni Musso, Maurizio Cassader, Roberto Gambino

引用次数: 0

Abstract

Duodenal mucosa ablation (DMA) is a novel approach to treat diabetes, consisting of endoscopic ablation of dysfunctional diabetic duodenal mucosa, which, following the healing response, is replaced by normally functioning mucosa. Two techniques, duodenal mucosal resurfacing (DMR) and recellularization via electroporation therapy (ReCET), recently showed promise in type 2 diabetes mellitus (T2DM) patients.

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内镜十二指肠粘膜消融术：糖尿病治疗的未来？

十二指肠粘膜消融术（DMA）是一种治疗糖尿病的新方法，它是通过内窥镜消融功能失调的糖尿病十二指肠粘膜，然后在愈合反应后由功能正常的粘膜取而代之。最近，十二指肠粘膜重铺（DMR）和电穿孔疗法再细胞化（ReCET）这两种技术在 2 型糖尿病（T2DM）患者中显示出良好的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.