Increasing the Water Solubility of N-Acyl-Substituted Amino Acid Esters as Inhibitors of the Replication of Modern Influenza A Virus Strains In Vitro by Zinc(II) Complexation

IF 1.8 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Russian Journal of Inorganic Chemistry Pub Date : 2024-03-28 DOI:10.1134/s0036023623603495

T. M. Garaev, I. I. Yudin, N. V. Breslav, T. E. Savochkina, A. S. Krepkaya, T. V. Grebennikova, S. E. Nikiforova, I. I. Myshletsov, V. V. Avdeeva, E. A. Malinina

引用次数: 0

Abstract

This article proposes carbocyclic derivatives of N-acylated esters of L-amino acids with aromatic carboxylic acids as antiviral small-molecule agents. To increase the water solubility of inhibitors that are insoluble in aqueous solutions, the target compounds were used as zinc(II) complexes. It has been shown that hydrophobic organic compounds in the form of zinc(II)-coordinated ligands are capable of suppressing the replication of the influenza A virus strain resistant to adamantane-type drugs. Zinc(II) chloride at the concentration used does not have antiviral or toxic effects in experiments in vitro.

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通过锌（II）络合增加 N-酰基取代的氨基酸酯作为现代甲型流感病毒株体外复制抑制剂的水溶性

摘要本文提出将 L-氨基酸与芳香族羧酸的 N-酰化酯的碳环衍生物作为抗病毒小分子药物。为了增加不溶于水溶液的抑制剂的水溶性，目标化合物被用作锌（II）配合物。研究表明，锌（II）配位体形式的疏水性有机化合物能够抑制对金刚烷类药物有抗药性的甲型流感病毒株的复制。在体外实验中，所使用浓度的氯化锌（II）没有抗病毒或毒性作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Journal of Inorganic Chemistry 化学-无机化学与核化学

CiteScore

3.10

自引率

38.10%

发文量

237

审稿时长

3 months

期刊介绍： Russian Journal of Inorganic Chemistry is a monthly periodical that covers the following topics of research: the synthesis and properties of inorganic compounds, coordination compounds, physicochemical analysis of inorganic systems, theoretical inorganic chemistry, physical methods of investigation, chemistry of solutions, inorganic materials, and nanomaterials.