Binding Studies of Novel Manganese Complexes to DNA

IF 1.8 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Russian Journal of Inorganic Chemistry Pub Date : 2024-03-28 DOI:10.1134/s0036023623603033

B. Wang, X. Y. Ma, W. Yao, S. Y. Wu, Y. Zhang, W. Liu, E. J. Gao

引用次数: 0

Abstract

A new Mn(II) complex was designed and synthesized in hydrothermal conditions using phenylmalonic acid and phosphine as raw materials. The effective characterization method was single-crystal X-ray diffraction. Besides, the interaction with FS-DNA (fish sperm DNA) and the DNA binding constants of the complex were determined by UV spectroscopy. The results showed that it was a significant apoptotic effect on cancer cells; therefore, the synthesized Mn(II) complex is important for the treatment of cancer.

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新型锰配合物与 DNA 的结合研究

摘要以苯基丙二酸和膦为原料，在水热条件下设计并合成了一种新的锰(II)配合物。单晶 X 射线衍射是有效的表征方法。此外，还利用紫外光谱测定了复合物与 FS-DNA（鱼精 DNA）的相互作用以及 DNA 结合常数。结果表明，该复合物对癌细胞有明显的凋亡作用，因此对治疗癌症有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Journal of Inorganic Chemistry 化学-无机化学与核化学

CiteScore

3.10

自引率

38.10%

发文量

237

审稿时长

3 months

期刊介绍： Russian Journal of Inorganic Chemistry is a monthly periodical that covers the following topics of research: the synthesis and properties of inorganic compounds, coordination compounds, physicochemical analysis of inorganic systems, theoretical inorganic chemistry, physical methods of investigation, chemistry of solutions, inorganic materials, and nanomaterials.