Methods behind oncolytic virus-based DC vaccines in cancer: Toward a multiphase combined treatment strategy for Glioblastoma (GBM) patients.

4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Methods in cell biology Pub Date : 2024-01-01 Epub Date: 2023-10-19 DOI:10.1016/bs.mcb.2023.06.001

Stefaan W Van Gool, Peter Van de Vliet, Linde F C Kampers, Jennifer Kosmal, Tobias Sprenger, Ella Reich, Volker Schirrmacher, Wilfried Stuecker

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引用次数: 0

Abstract

Glioblastoma (GBM) remains an orphan cancer disease with poor outcome. Novel treatment strategies are needed. Immunotherapy has several modes of action. The addition of active specific immunotherapy with dendritic cell vaccines resulted in improved overall survival of patients. Integration of DC vaccination within the first-line combined treatment became a challenge, and immunogenic cell death immunotherapy during chemotherapy was introduced. We used a retrospective analysis using real world data to evaluate the complex combined treatment, which included individualized multimodal immunotherapy during and after standard of care, and which required adaptations during treatment, and found a further improvement of overall survival. We also discuss the use of real world data as evidence. Novel strategies to move the field of individualized multimodal immunotherapy forward for GBM patients are reviewed.

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基于溶瘤病毒的直流电疫苗治疗癌症的方法：针对胶质母细胞瘤（GBM）患者的多阶段综合治疗策略。

胶质母细胞瘤（GBM）仍然是一种治疗效果不佳的孤儿癌症。我们需要新的治疗策略。免疫疗法有多种作用模式。使用树突状细胞疫苗进行主动特异性免疫治疗可提高患者的总生存率。将树突状细胞疫苗接种纳入一线综合治疗成为一项挑战，因此在化疗期间引入了免疫原性细胞死亡免疫疗法。我们利用真实世界的数据进行了回顾性分析，评估了复杂的联合治疗，其中包括标准治疗期间和之后的个体化多模式免疫疗法，以及治疗期间需要进行的调整，结果发现总生存率得到了进一步提高。我们还讨论了使用真实世界的数据作为证据的问题。我们还回顾了推动 GBM 患者个体化多模式免疫疗法领域发展的新策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Methods in cell biology 生物-细胞生物学

CiteScore

3.10

自引率

0.00%

发文量

125

审稿时长

3 months

期刊介绍： For over fifty years, Methods in Cell Biology has helped researchers answer the question "What method should I use to study this cell biology problem?" Edited by leaders in the field, each thematic volume provides proven, state-of-art techniques, along with relevant historical background and theory, to aid researchers in efficient design and effective implementation of experimental methodologies. Over its many years of publication, Methods in Cell Biology has built up a deep library of biological methods to study model developmental organisms, organelles and cell systems, as well as comprehensive coverage of microscopy and other analytical approaches.