EPR Investigation of Gamma-Irradiated Tiopronin

IF 1.1 4区物理与天体物理 Q4 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

Applied Magnetic Resonance Pub Date : 2024-03-28 DOI:10.1007/s00723-024-01645-z

Kerem Sütçü, Yunus Emre Osmanoğlu

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Abstract

This research delves into the radiation sensitivities of tiopronin when exposed to gamma irradiation within the 2–20 kGy dose range. This particular drug sample is commonly employed in the treatment of severe homozygous cystinuria. The paramagnetic species detected within tiopronin were ascribed to the presence of the -HNĊHCOOH- radical. The g factor and hyperfine constants for H atoms were computed as follows: a_α = 1.60 mT, a_β = 1.11 mT, a_N = 0.87 mT, and g = 2.0225 ± 0.0005. In the spectra recorded across different microwave power ranges, it was found that all signals exhibited the most favorable correlations with polynomial and logarithmic functions. It was established that the experimental data within the spectra recorded across the 2–20 kGy dose range exhibited a high degree of compatibility with power and polynomial functions. Obtaining EPR signals in the spectra recorded at high temperatures and after approximately 3 months showed that stable radicals were formed in the structure as a result of irradiation.

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伽马辐照硫普罗宁的 EPR 研究

这项研究深入探讨了硫普罗宁在 2-20 kGy 剂量范围内接受伽马辐照时的辐射敏感性。这种特殊的药物样本通常用于治疗严重的同型胱氨酸尿症。在硫普罗宁中检测到的顺磁物种是由于存在-HNĊHCOOH-自由基。H 原子的 g 因子和超细常数计算如下：aα = 1.60 mT，aβ = 1.11 mT，aN = 0.87 mT，g = 2.0225 ± 0.0005。在不同微波功率范围内记录的光谱中，发现所有信号都与多项式和对数函数表现出最有利的相关性。实验证明，在 2-20 kGy 剂量范围内记录的光谱中的实验数据与功率和多项式函数具有高度的兼容性。在高温和大约 3 个月后记录的光谱中获得的 EPR 信号表明，辐照在结构上形成了稳定的自由基。

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来源期刊

Applied Magnetic Resonance 物理-光谱学

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

2.3 months

期刊介绍： Applied Magnetic Resonance provides an international forum for the application of magnetic resonance in physics, chemistry, biology, medicine, geochemistry, ecology, engineering, and related fields. The contents include articles with a strong emphasis on new applications, and on new experimental methods. Additional features include book reviews and Letters to the Editor.