Preoperative activation of the Renin–Angiotensin system and myocardial injury in noncardiac surgery: Post Hoc Analysis of the SPACE randomised controlled Trial
Ana Gutierrez del Arroyo, Tom. E. F. Abbott, Akshaykumar Patel, Salma Begum, Priyanthi Dias, David Brealey, Rupert M. Pearse, Vikas Kapil, Gareth L. Ackland, the SPACE trial investigators
{"title":"Preoperative activation of the Renin–Angiotensin system and myocardial injury in noncardiac surgery: Post Hoc Analysis of the SPACE randomised controlled Trial","authors":"Ana Gutierrez del Arroyo, Tom. E. F. Abbott, Akshaykumar Patel, Salma Begum, Priyanthi Dias, David Brealey, Rupert M. Pearse, Vikas Kapil, Gareth L. Ackland, the SPACE trial investigators","doi":"10.1101/2024.03.22.24304763","DOIUrl":null,"url":null,"abstract":"<strong>Background</strong> Hypertension therapy in older adults is often suboptimal, in part due to inadequate suppression of the renin-angiotensin-aldosterone system (RAAS). We hypothesised that distinct endotypes of RAAS activation before noncardiac surgery are associated with increased risk of myocardial injury.","PeriodicalId":501303,"journal":{"name":"medRxiv - Anesthesia","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Anesthesia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.03.22.24304763","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background Hypertension therapy in older adults is often suboptimal, in part due to inadequate suppression of the renin-angiotensin-aldosterone system (RAAS). We hypothesised that distinct endotypes of RAAS activation before noncardiac surgery are associated with increased risk of myocardial injury.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
