Bioinspired 4D Printing Shape-Memory Polyurethane Rhinoplasty Prosthesis for Dynamic Aesthetic Adjustment

IF 4.9 3区计算机科学 Q1 ENGINEERING, MULTIDISCIPLINARY

Journal of Bionic Engineering Pub Date : 2024-03-27 DOI:10.1007/s42235-024-00503-9

Jiaqi Liu, Guiwei Li, He Liu, Jincheng Wang, Hui Wang, Xue Gao, Qingping Liu, Chenyu Wang

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Abstract

The disparity between the postoperative outcomes of rhinoplasty and the expected results frequently necessitates secondary or multiple surgeries as a compensatory measure, greatly diminishing patient satisfaction. However, there is renewed optimism for addressing these challenges through the innovative realm of Four-Dimensional (4D) printing. This groundbreaking technology enables three-dimensional objects with shape-memory properties to undergo predictable transformations under specific external stimuli. Consequently, implants crafted using 4D printing offer significant potential for dynamic adjustments. Inspired by worms in our research, we harnessed 4D printing to fabricate a Shape-Memory Polyurethane (SMPU) for use as a nasal augmentation prosthesis. The choice of SMPU was guided by its Glass Transition Temperature (T_g), which falls within the acceptable temperature range for the human body. This attribute allowed for temperature-responsive intraoperative self-deformation and postoperative remodeling. Our chosen animal model for experimentation was rabbits. Taking into account the anatomical structure of the rabbit nose, we designed and produced nasal augmentation prostheses with superior biocompatibility. These prostheses were then surgically implanted in a minimally invasive manner into the rabbit noses. Remarkably, they exhibited successful temperature-controlled in-surgery self-deformation according to the predetermined shape and non-invasive remodeling within a mere 9 days post-surgery. Subsequent histological evaluations confirmed the practical viability of these prostheses in a living organism. Our research findings posit that worm-inspired 4D-printed SMPU nasal prostheses hold significant promise for achieving dynamic aesthetic adjustments.

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用于动态美学调整的生物启发 4D 打印形状记忆聚氨酯隆鼻假体

摘要鼻整形术的术后效果与预期效果之间存在差距，经常需要进行二次或多次手术作为补偿措施，从而大大降低了患者的满意度。然而，通过创新的四维（4D）打印技术，解决这些难题的前景重新变得乐观起来。这项突破性技术可使具有形状记忆特性的三维物体在特定外部刺激下发生可预测的变化。因此，使用四维打印技术制作的植入物具有很大的动态调整潜力。受研究中蠕虫的启发，我们利用 4D 打印技术制造了一种形状记忆聚氨酯（SMPU），用作鼻假体。之所以选择 SMPU，是因为它的玻璃转化温度（Tg）在人体可接受的温度范围内。这一特性允许术中自我变形和术后重塑的温度反应。我们选择的实验动物模型是兔子。考虑到兔鼻的解剖结构，我们设计并制作了生物相容性极佳的鼻假体。然后，我们通过微创手术将这些假体植入兔鼻中。值得注意的是，这些假体在手术中成功地按照预定形状进行了温控自我变形，并在术后短短 9 天内实现了非侵入性重塑。随后的组织学评估证实了这些假体在活体中的实际可行性。我们的研究结果表明，由蠕虫启发的 4D 打印 SMPU 鼻假体在实现动态美学调整方面前景广阔。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bionic Engineering 工程技术-材料科学：生物材料

CiteScore

7.10

自引率

10.00%

发文量

162

审稿时长

10.0 months

期刊介绍： The Journal of Bionic Engineering (JBE) is a peer-reviewed journal that publishes original research papers and reviews that apply the knowledge learned from nature and biological systems to solve concrete engineering problems. The topics that JBE covers include but are not limited to: Mechanisms, kinematical mechanics and control of animal locomotion, development of mobile robots with walking (running and crawling), swimming or flying abilities inspired by animal locomotion. Structures, morphologies, composition and physical properties of natural and biomaterials; fabrication of new materials mimicking the properties and functions of natural and biomaterials. Biomedical materials, artificial organs and tissue engineering for medical applications; rehabilitation equipment and devices. Development of bioinspired computation methods and artificial intelligence for engineering applications.