PANINI: Combined protein and nucleic acid imaging in tissues

IF 67.7 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2024-03-28 DOI:10.1038/s41577-024-01028-2

Sizun Jiang

引用次数: 0

Abstract

Sizun Jiang (while in the Garry Nolan lab) describes a method termed PANINI that allows simultaneous detection of nucleic acids at low copy numbers and protein markers in intact tissues, offering valuable insights into virus–immune system interactions and beyond.

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PANINI：组织中的蛋白质和核酸组合成像

Sizun Jiang（在 Garry Nolan 实验室工作期间）介绍了一种名为 PANINI 的方法，该方法可同时检测完整组织中低拷贝数的核酸和蛋白质标记物，为了解病毒与免疫系统的相互作用及其他方面提供了宝贵的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.