The Effect of Surgical Procedure in the Nasal Cavity on the Passive Avoidance Conditioning and the Hypothalamic Level of Monoamines in Rats.

Q3 Agricultural and Biological Sciences

Doklady Biological Sciences Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI:10.1134/S0012496624700959

A G Korolev, I V Kastyro, A N Inozemtsev, A V Latanov

引用次数: 0

Abstract

A rat biological model of septoplasty was used to study the effect of surgery on passive avoidance conditioning (PAC). Septoplasty was shown to increase anxiety and to reduce exploratory activity in rodents during PAC. A neurochemical analysis of the hypothalamus was carried out immediately after the end of the experiment and showed an increase in norepinephrine (NE) metabolism after septoplasty. The finding was tentatively associated with activation of the hypothalamic-pituitary-adrenal axis.

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鼻腔手术对大鼠被动回避条件反射和下丘脑单胺类物质水平的影响

我们利用大鼠鼻中隔成形术生物模型来研究手术对被动回避条件反射（PAC）的影响。结果表明，在 PAC 过程中，鼻中隔成形术会增加啮齿动物的焦虑并减少其探索活动。实验结束后立即对下丘脑进行了神经化学分析，结果表明隔膜成形术后去甲肾上腺素（NE）代谢增加。这一发现初步与激活下丘脑-垂体-肾上腺轴有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Doklady Biological Sciences Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Doklady Biological Sciences is a journal that publishes new research in biological sciences of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.