Evaluation of tadalafil supplementation on the neutrophil/lymphocyte and the platelet/lymphocyte ratios in patients with erectile dysfunction: A prospective study.

IF 0.8 Q4 UROLOGY & NEPHROLOGY
Urologia Journal Pub Date : 2024-08-01 Epub Date: 2024-03-26 DOI:10.1177/03915603241240649
Sameh Fayek GamalEl Din, Nashaat Nabil Ismail, Hanan Hosni Moawad, Iten Mohamed Adel, Ahmad Motawi, Hisham Foaad
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引用次数: 0

Abstract

Objectives: We aimed to evaluate the effect of daily 5 mg tadalafil on the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) in patients with erectile dysfunction (ED).

Patients and methods: 30 subjects with ED were given tadalafil as well as 30 subjects with ED who were not receiving tadalafil were recruited. 30 healthy individuals served as controls.

Results: Receiver operating characteristic curve (ROC) showed that the best cut off point of pre-treatment and post treatment NLR in the ED treatment group was found <1.51, <1.51, sensitivity of 68.3%, 58.3%, specificity of 53.3%, 53.3%, lower bound of 0.558, 0.517, upper bound of 0.789, 0.757, total accuracy of 67.4%, 63.7% and p 0.003, 0.0025, respectively. Additionally, the best cut off point of pre-treatment and post treatment PLR in the ED treatment group was found <5.89, <5.99, sensitivity of 65%, 63.3%, specificity of 63.3%, 53.3%, lower bound of 0.515, 0.435, upper bound of 0.755, 0.687, total accuracy of 63.5%, 56.1% and p 0.027, 0.341, respectively.

Conclusion: Daily 5 mg Tadalafil supplementation significantly improves erectile function through decreasing these markers as well as depression and anxiety.

评估他达拉非补充剂对勃起功能障碍患者中性粒细胞/淋巴细胞和血小板/淋巴细胞比率的影响:前瞻性研究。
研究目的患者和方法:我们招募了30名服用他达拉非的ED患者和30名未服用他达拉非的ED患者。30名健康人作为对照组:接收操作特征曲线(ROC)显示,ED 治疗组治疗前和治疗后 NLR 的最佳临界点分别为 p 0.003 和 0.0025。此外,ED 治疗组治疗前和治疗后 PLR 的最佳临界点分别为 p 0.027 和 0.341:结论:每日补充 5 毫克他达拉非能通过降低这些指标以及抑郁和焦虑,明显改善勃起功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Urologia Journal
Urologia Journal UROLOGY & NEPHROLOGY-
CiteScore
0.60
自引率
12.50%
发文量
66
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