HIV/HBV coinfection: understanding the complex interactions and their impact on spontaneous HBV clearance, chronic liver damage, cirrhosis, and hepatocellular carcinoma.

IF 1.9 4区医学 Q4 IMMUNOLOGY

AIDS reviews Pub Date : 2024-01-01 DOI:10.24875/AIDSRev.23000019

Jingwen Xiao, Yongzheng Zhang, Jia Wu, Xinping -Chen, Wei Zou

引用次数: 0

Abstract

Compared to either HIV or hepatitis B virus (HBV) monoinfected individuals, HIV/HBV-coinfected individuals have a decreased probability of spontaneous HBV clearance and a greater risk of developing chronic liver damage and a faster progression to cirrhosis and hepatocellular carcinoma. This manuscript attempts to provide a comprehensive review of the landscape of current HIV/HBV coinfection research with a focus on the intricate interactions between these two viruses. Our review will help understand the disease dynamics of HIV/HBV coinfection and has important implications for designing public health strategies.

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HIV/HBV 合并感染：了解复杂的相互作用及其对自发性 HBV 清除、慢性肝损伤、肝硬化和肝细胞癌的影响。

与艾滋病病毒或乙型肝炎病毒（HBV）单一感染者相比，艾滋病病毒/乙型肝炎病毒双重感染者自发清除 HBV 的几率更低，发生慢性肝损伤的风险更大，发展为肝硬化和肝细胞癌的速度更快。本手稿试图全面回顾当前 HIV/HBV 合并感染的研究现状，重点关注这两种病毒之间错综复杂的相互作用。我们的综述将有助于理解 HIV/HBV 合并感染的疾病动力学，并对设计公共卫生策略具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS reviews 医学-传染病学

CiteScore

3.40

自引率

4.50%

发文量

审稿时长

>12 weeks

期刊介绍： AIDS Reviews publishes papers reporting original scientific, clinical, epidemiologic and social research which contribute to the overall knowledge of the field of the acquired immunodeficiency syndrome and human retrovirology. Currently, the Journal publishes review articles (usually by invitation, but spontaneous submitted articles will also be considered). Manuscripts submitted to AIDS Reviews will be accepted on the understanding that the authors have not submitted the paper to another journal or published the material elsewhere.