Cellular and molecular mechanisms involved in the analgesic effects of botulinum neurotoxin: A literature review

IF 3.5 4区医学 Q2 CHEMISTRY, MEDICINAL

Drug Development Research Pub Date : 2024-03-25 DOI:10.1002/ddr.22177

Saereh Hosseindoost, Seyed Hassan Inanloo, Seyed Khalil Pestehei, Mojgan Rahimi, Reza Atef Yekta, Alireza Khajehnasiri, Maziyar Askari Rad, Hossein Majedi, Ahmad Reza Dehpour

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引用次数: 0

Abstract

Botulinum neurotoxins (BoNTs), derived from Clostridium botulinum, have been employed to treat a range of central and peripheral neurological disease. Some studies indicate that BoNT may be beneficial for pain conditions as well. It has been hypothesized that BoNTs may exert their analgesic effects by preventing the release of pain-related neurotransmitters and neuroinflammatory agents from sensory nerve endings, suppressing glial activation, and inhibiting the transmission of pain-related receptors to the neuronal cell membrane. In addition, there is evidence to suggest that the central analgesic effects of BoNTs are mediated through their retrograde axonal transport. The purpose of this review is to summarize the experimental evidence of the analgesic functions of BoNTs and discuss the cellular and molecular mechanisms by which they can act on pain conditions. Most of the studies reviewed in this article were conducted using BoNT/A. The PubMed database was searched from 1995 to December 2022 to identify relevant literature.

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肉毒杆菌神经毒素镇痛作用的细胞和分子机制：文献综述。

肉毒杆菌神经毒素（BoNTs）源自肉毒杆菌，已被用于治疗一系列中枢和周围神经疾病。一些研究表明，BoNT 对疼痛病症也可能有益。据推测，BoNTs 可通过阻止感觉神经末梢释放与疼痛有关的神经递质和神经炎症因子、抑制神经胶质细胞的活化以及抑制与疼痛有关的受体向神经元细胞膜的传递来发挥镇痛作用。此外，有证据表明，BoNTs 的中枢镇痛作用是通过其轴突逆向运输介导的。本综述旨在总结 BoNTs 镇痛功能的实验证据，并讨论其作用于疼痛状况的细胞和分子机制。本文回顾的大多数研究都是使用 BoNT/A 进行的。我们检索了 1995 年至 2022 年 12 月的 PubMed 数据库，以确定相关文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Development Research 医学-药学

CiteScore

6.40

自引率

2.60%

发文量

104

审稿时长

6-12 weeks

期刊介绍： Drug Development Research focuses on research topics related to the discovery and development of new therapeutic entities. The journal publishes original research articles on medicinal chemistry, pharmacology, biotechnology and biopharmaceuticals, toxicology, and drug delivery, formulation, and pharmacokinetics. The journal welcomes manuscripts on new compounds and technologies in all areas focused on human therapeutics, as well as global management, health care policy, and regulatory issues involving the drug discovery and development process. In addition to full-length articles, Drug Development Research publishes Brief Reports on important and timely new research findings, as well as in-depth review articles. The journal also features periodic special thematic issues devoted to specific compound classes, new technologies, and broad aspects of drug discovery and development.