Assessment of aspartate aminotransferase to Platelet Ratio Index and Fibrosis-4 Index score on women with intrahepatic cholestasis of pregnancy

AJOG global reports Pub Date : 2024-03-10 DOI:10.1016/j.xagr.2024.100337

Maria Cemortan PhD, Corina Iliadi-Tulbure PhD, Irina Sagaidac PhD, Olga Cernetchi PhD

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引用次数: 0

Abstract

BACKGROUND

Intrahepatic cholestasis of pregnancy is a pregnancy-related liver condition that is characterized by elevated liver function tests and/or bile acids in the presence of pruritis.

OBJECTIVE

The study aimed to assess the aspartate aminotransferase to Platelet Ratio Index and Fibrosis-4 Index scores in intrahepatic cholestasis of pregnancy.

STUDY DESIGN

The prospective study was carried out by assessing 142 women: 71 whose pregnancies were complicated by intrahepatic cholestasis of pregnancy and 71 without intrahepatic cholestasis of pregnancy. The Fibrosis-4 Index score and aspartate aminotransferase to Platelet Ratio Index were assessed.

RESULTS

Our findings indicate that both aspartate aminotransferase to Platelet Ratio Index and Fibrosis-4 Index scores were reliable indicators of intrahepatic cholestasis of pregnancy, correlating with important complications of the condition.

CONCLUSION

This study provides valuable information to help clinicians better diagnose and perform the management of intrahepatic cholestasis of pregnancy.

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评估妊娠期肝内胆汁淤积症妇女的 apri 和 fib-4 评分

背景妊娠期肝内胆汁淤积症是一种与妊娠有关的肝脏疾病，其特点是肝功能检查和/或胆汁酸升高并伴有瘙痒。研究设计这项前瞻性研究对 142 名妇女进行了评估，其中 71 名妇女的妊娠合并有妊娠期肝内胆汁淤积症，71 名妇女没有妊娠期肝内胆汁淤积症。结果我们的研究结果表明，天门冬氨酸氨基转移酶与血小板比值指数和纤维化-4指数评分都是妊娠期肝内胆汁淤积症的可靠指标，与病情的重要并发症相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AJOG global reports Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Perinatology, Pediatrics and Child Health, Urology

CiteScore

1.20

自引率

0.00%

发文量