Tirzepatide-induced ketoacidosis in non-diabetic patients

Q3 Medicine

European journal of case reports in internal medicine Pub Date : 2024-03-11 DOI:10.12890/2024_004357

Pathan Mohamad Rafe Iqbal, O. Maadarani, Z. Bitar

引用次数: 0

Abstract

Background: Tirzepatide is a novel glucagon-like peptide 1/glucose-dependent insulinotropic peptide (GLP-1/GIP) receptor agonist. It was recently approved for diabetes control and weight reduction in non-diabetic patients. Case description: We report the first case of ketoacidosis after the use of tirzepatide in an obese non-diabetic patient, secondary to the possibility of starvation ketoacidosis and insulin resistance. Conclusion: The dual-acting GLP-1 and GIP receptor agonists, tirzepatide, can induce ketoacidosis in obese non-diabetic patients.

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非糖尿病患者因替氮帕肽引起的酮症酸中毒

背景：替扎帕肽是一种新型胰高血糖素样肽 1/葡萄糖依赖性促胰岛素肽（GLP-1/GIP）受体激动剂。它最近被批准用于控制糖尿病和减轻非糖尿病患者的体重。病例描述我们报告了首例肥胖非糖尿病患者使用替扎帕肽后出现酮症酸中毒的病例，继发原因可能是饥饿性酮症酸中毒和胰岛素抵抗。结论双效 GLP-1 和 GIP 受体激动剂替扎帕肽可诱发肥胖非糖尿病患者酮症酸中毒。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European journal of case reports in internal medicine

CiteScore

2.10

自引率

0.00%

发文量

166

审稿时长

8 weeks

期刊介绍： The European Journal of Case Reports in Internal Medicine is an official journal of the European Federation of Internal Medicine (EFIM), representing 35 national societies from 33 European countries. The Journal''s mission is to promote the best medical practice and innovation in the field of acute and general medicine. It also provides a forum for internal medicine doctors where they can share new approaches with the aim of improving diagnostic and clinical skills in this field. EJCRIM welcomes high-quality case reports describing unusual or complex cases that an internist may encounter in everyday practice. The cases should either demonstrate the appropriateness of a diagnostic/therapeutic approach, describe a new procedure or maneuver, or show unusual manifestations of a disease or unexpected reactions. The Journal only accepts and publishes those case reports whose learning points provide new insight and/or contribute to advancing medical knowledge both in terms of diagnostics and therapeutic approaches. Case reports of medical errors, therefore, are also welcome as long as they provide innovative measures on how to prevent them in the current practice (Instructive Errors). The Journal may also consider brief and reasoned reports on issues relevant to the practice of Internal Medicine, as well as Abstracts submitted to the scientific meetings of acknowledged medical societies.

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