Synthesis, characterisation, and anticancer and antioxidant activities of novel complexes of palladium and an organic Schiff-base ligand

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Bulletin of the Chemical Society of Ethiopia Pub Date : 2024-03-12 DOI:10.4314/bcse.v38i3.5

Muhammad H. Khalil, Fuad O. Abdullah

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引用次数: 0

Abstract

Treatment of the Schiff base 2-N-(salicylidene) benzothiazole (SabtH) with palladium chloride afforded the neutral 2-N-(salicylidene) benzothiazole palladium(II) complex. This was then treated with one molar equivalent of either ethylenediamine or 1,10-phenanthroline, yielding the neutral mixed ligand complexes 1 and 2, respectively. The prepared organic ligand and its mixed ligand complexes were characterised via UV-Vis, FTIR, 1H-NMR, and 13C-NMR spectroscopy. The antiproliferative activities of 1 and 2 were tested against MCF-7 (breast) and HT-29 (colon) cancer cells using an MTT assay. 1 showed strong antiproliferative activity against both MCF-7 and HT-29 cancer cells, with IC50 values of 74.6 ± 8.35 and 174 ± 20.28 µg/mL, respectively. In addition, 2 exhibited the maximum antioxidant activity, with an EC50 value of 1029 ± 196.76 µg/mL. KEY WORDS: 2-N-(Salicylidene) benzothiazole, 1,10-Phenanthroline, Palladium mixed ligand complexes, Anticancer, Antioxidant activity Bull. Chem. Soc. Ethiop. 2024, 38(3), 605-613. DOI: https://dx.doi.org/10.4314/bcse.v38i3.5

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钯与有机席夫碱配体新型配合物的合成、表征、抗癌和抗氧化活性

用氯化钯处理希夫碱 2-N-（水杨醛基）苯并噻唑（SabtH），可得到中性的 2-N-（水杨醛基）苯并噻唑钯（II）络合物。然后用一个摩尔当量的乙二胺或 1,10-菲罗啉处理，分别得到中性混合配体络合物 1 和 2。制备的有机配体及其混合配体复合物通过紫外可见光谱、傅立叶变换红外光谱、1H-NMR 和 13C-NMR 光谱进行了表征。利用 MTT 法测试了 1 和 2 对 MCF-7（乳腺癌）和 HT-29（结肠癌）癌细胞的抗增殖活性。1 对 MCF-7 和 HT-29 癌细胞都表现出很强的抗增殖活性，IC50 值分别为 74.6 ± 8.35 和 174 ± 20.28 µg/mL。此外，2 表现出最大的抗氧化活性，其 EC50 值为 1029 ± 196.76 µg/mL。关键词：2-N-（水杨醛）苯并噻唑、1,10-菲罗啉、钯混合配体配合物、抗癌、抗氧化活性 Bull.Chem.Soc.2024, 38(3), 605-613. DOI: https://dx.doi.org/10.4314/bcse.v38i3.5

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来源期刊

Bulletin of the Chemical Society of Ethiopia 化学-化学综合

CiteScore

2.20

自引率

8.30%

发文量

113

审稿时长

6-12 weeks

期刊介绍： The Bulletin of the Chemical Society of Ethiopia (BCSE) is a triannual publication of the Chemical Society of Ethiopia. The BCSE is an open access and peer reviewed journal. The BCSE invites contributions in any field of basic and applied chemistry.