Distribution of anticoagulant resistance in the brown rat in Belgium

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-14 DOI:10.26496/bjz.2012.135

K. Baert, J. Stuyck, P. Breyne, D. Maes, J. Casaer

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引用次数: 28

Abstract

Anticoagulant resistance is known as one of the major factors interfering with rodent control. Within this context we investigated the distribution of anticoagulant resistance in Flanders, northern Belgium. From 2003 to 2005, we tested 691 rats from different locations with blood clotting response tests for their susceptibility to the anticoagulant compounds warfarin, bromadiolone and difenacoum. Of these, 119 were also screened for a mutation in the VKORC1 gene that is suspected to be responsible for anticoagulant resistance. Warfarin resistant rats were found in the western and eastern parts of Flanders. The same distribution pattern was found for bromadiolone with the exception of the south-eastern area, where this form of resistance was largely absent. We detected difenacoum resistance in only six rats and did not observe any resistant rats in the central part of Flanders. Susceptible rats were found all over Flanders. Genetic analyses showed that anticoagulant resistance in Belgium was related to two different mutations in VKORC1, namely Y139F and L120Q. Our results indicate that rodent control should be regionally tailored to be most effective.

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比利时褐鼠抗凝血剂耐药性的分布情况

众所周知，抗凝血剂抗药性是影响鼠类控制的主要因素之一。在这种情况下，我们调查了比利时北部佛兰德斯地区抗凝血剂抗药性的分布情况。从 2003 年到 2005 年，我们对来自不同地区的 691 只老鼠进行了凝血反应测试，以了解它们对华法林、溴敌隆和鼠得克等抗凝血剂化合物的敏感性。其中 119 只老鼠还接受了 VKORC1 基因突变筛查，该基因突变被怀疑是导致抗凝血剂耐药性的原因。在佛兰德斯的西部和东部地区发现了对华法林产生抗药性的老鼠。溴敌隆也发现了同样的分布模式，但东南部地区除外，该地区基本上不存在这种抗药性。我们只在六只老鼠身上检测到了鼠得克的抗药性，在佛兰德斯中部地区没有发现任何抗药性老鼠。易感大鼠遍布佛兰德地区。基因分析表明，比利时的抗凝剂抗药性与 VKORC1 的两种不同突变（即 Y139F 和 L120Q）有关。我们的研究结果表明，啮齿动物控制工作应根据不同地区的具体情况进行，这样才能取得最佳效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.