Olesya Kuznetsova, M. Fedyanin, Larisa Zavalishina, Larisa Moskvina, Olga Kuznetsova, Alexandra Lebedeva, Alexey Tryakin, Galina Kireeva, Gleb Borshchev, Sergei Tjulandin, Ekaterina Ignatova
{"title":"Prognostic and predictive role of immune microenvironment in colorectal cancer","authors":"Olesya Kuznetsova, M. Fedyanin, Larisa Zavalishina, Larisa Moskvina, Olga Kuznetsova, Alexandra Lebedeva, Alexey Tryakin, Galina Kireeva, Gleb Borshchev, Sergei Tjulandin, Ekaterina Ignatova","doi":"10.4251/wjgo.v16.i3.643","DOIUrl":null,"url":null,"abstract":"Colorectal cancer (CRC) represents a molecularly heterogeneous disease and one of the most frequent causes of cancer-related death worldwide. The traditional classification of CRC is based on pathomorphological and molecular characteristics of tumor cells (mucinous, ring-cell carcinomas, etc. ), analysis of mechanisms of carcinogenesis involved (chromosomal instability, microsatellite instability, CpG island methylator phenotype) and mutational statuses of commonly altered genes (KRAS, NRAS, BRAF, APC, etc. ), as well as expression signatures (CMS 1-4). It is also suggested that the tumor microenvironment is a key player in tumor progression and metastasis in CRC. According to the latest data, the immune microenvironment can also be predictive of the response to immune checkpoint inhibitors. In this review, we highlight how the immune environment influences CRC prognosis and sensitivity to systemic therapy.","PeriodicalId":504226,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"57 5","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Gastrointestinal Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4251/wjgo.v16.i3.643","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Colorectal cancer (CRC) represents a molecularly heterogeneous disease and one of the most frequent causes of cancer-related death worldwide. The traditional classification of CRC is based on pathomorphological and molecular characteristics of tumor cells (mucinous, ring-cell carcinomas, etc. ), analysis of mechanisms of carcinogenesis involved (chromosomal instability, microsatellite instability, CpG island methylator phenotype) and mutational statuses of commonly altered genes (KRAS, NRAS, BRAF, APC, etc. ), as well as expression signatures (CMS 1-4). It is also suggested that the tumor microenvironment is a key player in tumor progression and metastasis in CRC. According to the latest data, the immune microenvironment can also be predictive of the response to immune checkpoint inhibitors. In this review, we highlight how the immune environment influences CRC prognosis and sensitivity to systemic therapy.
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