Prevalence of heart failure among hospitalized patient with T2D: results of a prospective observational multicenter study (CREDO)

IF 0.7 Q4 ENDOCRINOLOGY & METABOLISM
Diabetes Mellitus Pub Date : 2024-03-18 DOI:10.14341/dm13124
M. Antsiferov, Z. Kobalava, T. Demidova, T. N. Markova, V. V. Tolkacheva, L. Morgunov, A. V. Andreeva, Е. Y. Pashkova, M. R. Khaziakhmetova, E. S. Samburova, S. G. Vedyashkina, A. Mkrtumyan, N. Petunina, A. N. Serebrov, T. M. Deeva, A. Y. Karaeva
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Abstract

BACKROUND: Heart failure (HF) is in the first place in the structure of cardiovascular death in patients with type 2 diabetes mellitus (T2D). One of the factors determining the prognosis of patients with this pathology is hospitalization. The difficulties of managing patients are related to the heterogeneity of the population. In some cases, HF in patients with T2D remains undiagnosed, and data on the true frequency of HF in patients with T2D and their clinical and laboratory characteristics in real clinical practice remain limited.AIM: To assess the prevalence of HF, clinical and demographic characteristics and therapy profile in patients with T2D admitted to multidisciplinary hospitals.MATERIALS AND METHODS: A prospective observational multicenter study was conducted at the city clinical hospitals of the Moscow. For the period from August 2022 to April 2023, data from patients with T2D were analyzed. Data collection was carried out at one visit. The study design did not involve any intervention in routine clinical practice, including the choice of diagnostic method or treatment.RESULTS: The study included 445 patients in accordance with the main inclusion criteria - T2D, age over 50 years, duration of T2D more than 3 years. The incidence of HF in patients with type 2 diabetes at discharge was 76.6%. The diagnosis of HF was confirmed in 48.7% (n=217), newly diagnosed HF occurred in 27.9% (n=124) of cases, in 12.6% of patients (n=56) the diagnosis of HF was withdrawn, in 10.8% (n=48) of cases the diagnosis of HF was not established. The frequency of prescribing drugs at discharge was iSGLT-2 — 77.3% (n=344), statins — 86.7% (n= 386), MRAs — 23.1% (n=103), diure­tics — 46.1% (n=205).CONCLUSION: 76.6% of patients with T2D admitted to multidisciplinary Moscow hospitals were diagnosed with HF at discharge. The results obtained confirm the possibility of detecting HF and initiating cardioprotective therapy at the hospital stage, using inpatient clinical diagnostic examination, and patients with type 2 diabetes lasting more than 3 years and aged over 50 years can be classified as a high risk group for developing HF.
前瞻性多中心观察研究(CREDO)结果:T2D 住院患者中心力衰竭的患病率
背景:心力衰竭(HF)是 2 型糖尿病(T2D)患者心血管死亡的首要原因。决定这种病症患者预后的因素之一是住院治疗。管理患者的困难与人群的异质性有关。在某些情况下,T2D 患者中的高血压仍未得到诊断,而有关 T2D 患者中高血压的真实发病率及其在实际临床实践中的临床和实验室特征的数据仍然有限。研究分析了 2022 年 8 月至 2023 年 4 月期间 T2D 患者的数据。数据收集在一次就诊中进行。研究设计不涉及常规临床实践中的任何干预,包括诊断方法或治疗方法的选择。结果:研究纳入了 445 名符合主要纳入标准的患者--T2D、50 岁以上、T2D 病程超过 3 年。出院时,2 型糖尿病患者的心房颤动发生率为 76.6%。48.7%的患者(n=217)确诊为心房颤动,27.9%的患者(n=124)新诊断为心房颤动,12.6%的患者(n=56)撤销了心房颤动诊断,10.8%的患者(n=48)心房颤动诊断不成立。出院时处方药物的频率为:iSGLT-2-77.3%(n=344)、他汀类药物-86.7%(n=386)、MRAs-23.1%(n=103)、利尿剂-46.1%(n=205)。研究结果证实,通过住院临床诊断检查,可以在医院阶段发现心房颤动并启动心脏保护治疗,而且病程超过3年、年龄超过50岁的2型糖尿病患者可被列为心房颤动的高危人群。
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来源期刊
Diabetes Mellitus
Diabetes Mellitus ENDOCRINOLOGY & METABOLISM-
CiteScore
1.90
自引率
40.00%
发文量
61
审稿时长
7 weeks
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