Repeated use of hybrid isolated chemoperfusion with melphalan in non-resectable liver malignancy

Q4 Medicine

Siberian journal of oncology Pub Date : 2024-03-23 DOI:10.21294/1814-4861-2024-23-1-155-161

A. I. Babich, M. A. Privalov, A. Demko, V. Reva, V. A. Manukovskiy, V. Cheremisov, I. V. Reshetov

{"title":"Repeated use of hybrid isolated chemoperfusion with melphalan in non-resectable liver malignancy","authors":"A. I. Babich, M. A. Privalov, A. Demko, V. Reva, V. A. Manukovskiy, V. Cheremisov, I. V. Reshetov","doi":"10.21294/1814-4861-2024-23-1-155-161","DOIUrl":null,"url":null,"abstract":"Background. The incidence of liver malignancies is increasing, radical surgery can be performed in a small number of patients, most of them receive drug treatment. Isolated liver chemoperfusion (ILP) is a method of regional chemotherapy that is effective for some metastases but has a high complexity and frequency of complications. An improved method of hybrid ILP may offer new opportunities for patients with unresectable liver tumors. Case report. A 64-year-old patient diagnosed with stage IV sigmoid colon cancer underwent hybrid ILP. The patient was discharged after 6 days in a satisfactory condition without complications. Systemic chemotherapy was performed 21 days after the first hybrid chemoperfusion. The second hybrid chemoperfusion procedure was performed without the laparotomy stage, mobilizing the right common femoral vein and artery. As a result of the chemotherapy, the patients received a positive result on the mRECIST scale – a complete tumor response. Conclusion. The developed method of hybrid ILP has several advantages over traditional ILP and chemosaturation with infusion into the hepatic artery. This method can also be performed repeatedly, which is not possible with traditional ILP.","PeriodicalId":21881,"journal":{"name":"Siberian journal of oncology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Siberian journal of oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21294/1814-4861-2024-23-1-155-161","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background. The incidence of liver malignancies is increasing, radical surgery can be performed in a small number of patients, most of them receive drug treatment. Isolated liver chemoperfusion (ILP) is a method of regional chemotherapy that is effective for some metastases but has a high complexity and frequency of complications. An improved method of hybrid ILP may offer new opportunities for patients with unresectable liver tumors. Case report. A 64-year-old patient diagnosed with stage IV sigmoid colon cancer underwent hybrid ILP. The patient was discharged after 6 days in a satisfactory condition without complications. Systemic chemotherapy was performed 21 days after the first hybrid chemoperfusion. The second hybrid chemoperfusion procedure was performed without the laparotomy stage, mobilizing the right common femoral vein and artery. As a result of the chemotherapy, the patients received a positive result on the mRECIST scale – a complete tumor response. Conclusion. The developed method of hybrid ILP has several advantages over traditional ILP and chemosaturation with infusion into the hepatic artery. This method can also be performed repeatedly, which is not possible with traditional ILP.

查看原文本刊更多论文

在非切除性肝脏恶性肿瘤中重复使用美法仑混合隔离化学灌注疗法

背景。肝脏恶性肿瘤的发病率越来越高，少数患者可以进行根治性手术，大多数患者接受药物治疗。孤立肝脏化学灌注（ILP）是一种区域化疗方法，对某些转移瘤有效，但复杂性高，并发症频发。改进后的混合 ILP 方法可为无法切除的肝肿瘤患者提供新的治疗机会。病例报告。一名被诊断为乙状结肠癌 IV 期的 64 岁患者接受了混合 ILP。6 天后患者康复出院，情况良好，无并发症。第一次混合化学灌注 21 天后进行了全身化疗。第二次混合化学灌注手术在没有开腹手术的情况下进行，移动了右股总静脉和动脉。化疗后，患者的 mRECIST 评分结果呈阳性--肿瘤完全反应。结论与传统的 ILP 和肝动脉灌注化疗相比，所开发的混合 ILP 方法具有多项优势。这种方法还可以反复进行，而传统的 ILP 却无法做到这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Siberian journal of oncology Medicine-Oncology

CiteScore

0.40

自引率

0.00%

发文量

117

审稿时长

8 weeks

期刊介绍： The main objectives of the journal are: -to promote the establishment of Russia’s leading worldwide positions in the field of experimental and clinical oncology- to create the international discussion platform intended to cover all aspects of basic and clinical cancer research, including carcinogenesis, molecular biology, epidemiology, cancer prevention, diagnosis and multimodality treatment (surgery, chemotherapy, radiation therapy, hormone therapy), anesthetic management, medical and social rehabilitation, palliative care as well as the improvement of life quality of cancer patients- to encourage promising young scientists to be actively involved in cancer research programs- to provide a platform for researches and doctors all over the world to promote, share, and discuss various new issues and developments in cancer related problems. (to create a communication platform for the expansion of cooperation between Russian and foreign professional associations).- to provide the information about the latest worldwide achievements in different fields of oncology The most important tasks of the journal are: -to encourage scientists to publish their research results- to offer a forum for active discussion on topics of major interest - to invite the most prominent Russian and foreign authors to share their latest research findings with cancer research community- to promote the exchange of research information, clinical experience, current trends and the recent developments in the field of oncology as well as to review interesting cases encountered by colleagues all over the world- to expand the editorial board and reviewers with the involvement of well-known Russian and foreign experts- to provide open access to full text articles- to include the journal into the international database- to increase the journal’s impact factor- to promote the journal to the International and Russian markets

文献相关原料

公司名称	产品信息	采购帮参考价格