Kai Su, Peng Chen, Hao Gao, Yuan Zhai, Youbei Qiao, Chaoli Wang, Feng Yang
{"title":"Ionic Liquids Nanoliposomes Based on Targeted and Active Permeability for Enhanced Combination Chemotherapy Efficiency","authors":"Kai Su, Peng Chen, Hao Gao, Yuan Zhai, Youbei Qiao, Chaoli Wang, Feng Yang","doi":"10.1142/s1793292023501151","DOIUrl":null,"url":null,"abstract":"<p>Tumor microenvironment severely restricts the delivery of chemotherapy drugs. The microenvironment responsive nanoparticles often have complex designs with hampered clinical translatability. Here, we show a kind of ionic liquids (ILs) with soybean lecithin (SL) as cation, folic acid (FA) as anion, in particular, it could formulate nanoliposome by film evaporation method to deliver cis-Diamineplatinum (II) dichloride (cisplatin, Cis) and doxorubicin hydrochloride (DOX). These special ILs liposome could target tumor cells via folate receptor-mediated endocytosis by enhancing the cellular uptake, and significantly improve the deep permeability by actively infiltrating throughout the tumor tissue owing to the special noncovalent bond between SL–FA ILs with cell membrane. Moreover, ILs liposomes improve delivery efficiency of Cis and DOX and enhance the combined chemotherapeutic effect. The simple preparation process of the ILs nanoliposome should facilitate the clinical transformation of nanodrugs.</p>","PeriodicalId":18978,"journal":{"name":"Nano","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1142/s1793292023501151","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Tumor microenvironment severely restricts the delivery of chemotherapy drugs. The microenvironment responsive nanoparticles often have complex designs with hampered clinical translatability. Here, we show a kind of ionic liquids (ILs) with soybean lecithin (SL) as cation, folic acid (FA) as anion, in particular, it could formulate nanoliposome by film evaporation method to deliver cis-Diamineplatinum (II) dichloride (cisplatin, Cis) and doxorubicin hydrochloride (DOX). These special ILs liposome could target tumor cells via folate receptor-mediated endocytosis by enhancing the cellular uptake, and significantly improve the deep permeability by actively infiltrating throughout the tumor tissue owing to the special noncovalent bond between SL–FA ILs with cell membrane. Moreover, ILs liposomes improve delivery efficiency of Cis and DOX and enhance the combined chemotherapeutic effect. The simple preparation process of the ILs nanoliposome should facilitate the clinical transformation of nanodrugs.
期刊介绍：
NANO is an international peer-reviewed monthly journal for nanoscience and nanotechnology that presents forefront fundamental research and new emerging topics. It features timely scientific reports of new results and technical breakthroughs and also contains interesting review articles about recent hot issues.
NANO provides an ideal forum for presenting original reports of theoretical and experimental nanoscience and nanotechnology research. Research areas of interest include: nanomaterials including nano-related biomaterials, new phenomena and newly developed characterization tools, fabrication methods including by self-assembly, device applications, and numerical simulation, modeling, and theory. However, in light of the current stage development of nanoscience, manuscripts on numerical simulation, modeling, and/or theory only without experimental evidences are considered as not pertinent to the scope of NANO.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
