Affinity-independent plasma cell differentiation in germinal centers.

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2024-04-01 Epub Date: 2024-03-22 DOI:10.1016/j.it.2024.03.002

Roser Tachó-Piñot, Carola G Vinuesa

引用次数: 0

Abstract

The role of antibody affinity in plasma cell (PC) differentiation from germinal centers (GCs) remains contested. Parallel studies by Sprumont et al. and Sutton and Gao et al. show that PCs emerging from GCs produce antibodies with a diverse range of affinities and lack signatures of affinity-based selection. Therefore, commitment to the PC lineage is affinity independent.

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生殖中心中不依赖亲缘关系的浆细胞分化

抗体亲和力在浆细胞（PC）从生殖中心（GCs）分化中的作用仍存在争议。Sprumont 等人、Sutton 和 Gao 等人的平行研究表明，从生殖中心分化出来的 PC 产生的抗体具有多种亲和力，缺乏基于亲和力的选择特征。因此，对 PC 系的承诺与亲和力无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.