{"title":"Feasibility study of radioactivity estimation of <sup>99m</sup>Tc and <sup>123</sup>I-labeled radiopharmaceuticals using shielded syringes.","authors":"Yuto Nakamura, Narumi Yasuno","doi":"10.1007/s12194-024-00789-8","DOIUrl":null,"url":null,"abstract":"<p><p>This study investigates the feasibility of estimating the radioactivity of radiopharmaceuticals using shielded syringes. The radioactivities of <sup>99m</sup>Tc-MDP, <sup>99m</sup>Tc-HMDP, <sup>99m</sup>Tc-ECD, <sup>99m</sup>Tc-MAG<sub>3</sub>, and <sup>123</sup>I-IMP were measured using a dose calibrator. Correlation coefficients and regression equations were obtained from the radioactivity in the shielded and unshielded syringes. <sup>99m</sup>Tc-MDP was also measured for residual radioactivity after the administration. The correlation coefficients of <sup>99m</sup>Tc-MDP, <sup>99m</sup>Tc-HMDP, <sup>99m</sup>Tc-ECD, <sup>99m</sup>Tc-MAG<sub>3</sub>, and <sup>123</sup>I-IMP were r<sub>s</sub> = 0.9998, r<sub>s</sub> = 0.9997, r<sub>s</sub> = 0.9999, r<sub>s</sub> = 0.9998, and r<sub>s</sub> = 0.9888, respectively. The regression equations were y = 0.0364x + 0.0913, y = 0.0349x + 0.0273, y = 0.0343x - 0.0018, y = 0.0522x + 0.1215, and y = 0.0383x + 0.0058, respectively. The correlation coefficient for the residual radioactivity of <sup>99m</sup>Tc-MDP was r<sub>s</sub> = 0.9887 and the regression equation was y = 0.1505x + 0.0853. The radioactivity of <sup>99m</sup>Tc- and <sup>123</sup>I-labeled radiopharmaceuticals in shielded syringes was accurately measured. It was suggested that the measuring shielded syringes could provide an estimate of the actual radioactivity.</p>","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiological Physics and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12194-024-00789-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/22 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
This study investigates the feasibility of estimating the radioactivity of radiopharmaceuticals using shielded syringes. The radioactivities of 99mTc-MDP, 99mTc-HMDP, 99mTc-ECD, 99mTc-MAG3, and 123I-IMP were measured using a dose calibrator. Correlation coefficients and regression equations were obtained from the radioactivity in the shielded and unshielded syringes. 99mTc-MDP was also measured for residual radioactivity after the administration. The correlation coefficients of 99mTc-MDP, 99mTc-HMDP, 99mTc-ECD, 99mTc-MAG3, and 123I-IMP were rs = 0.9998, rs = 0.9997, rs = 0.9999, rs = 0.9998, and rs = 0.9888, respectively. The regression equations were y = 0.0364x + 0.0913, y = 0.0349x + 0.0273, y = 0.0343x - 0.0018, y = 0.0522x + 0.1215, and y = 0.0383x + 0.0058, respectively. The correlation coefficient for the residual radioactivity of 99mTc-MDP was rs = 0.9887 and the regression equation was y = 0.1505x + 0.0853. The radioactivity of 99mTc- and 123I-labeled radiopharmaceuticals in shielded syringes was accurately measured. It was suggested that the measuring shielded syringes could provide an estimate of the actual radioactivity.
期刊介绍:
The purpose of the journal Radiological Physics and Technology is to provide a forum for sharing new knowledge related to research and development in radiological science and technology, including medical physics and radiological technology in diagnostic radiology, nuclear medicine, and radiation therapy among many other radiological disciplines, as well as to contribute to progress and improvement in medical practice and patient health care.