Feasibility study of radioactivity estimation of 99mTc and 123I-labeled radiopharmaceuticals using shielded syringes.

IF 1.7 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Radiological Physics and Technology Pub Date : 2024-06-01 Epub Date: 2024-03-22 DOI:10.1007/s12194-024-00789-8
Yuto Nakamura, Narumi Yasuno
{"title":"Feasibility study of radioactivity estimation of <sup>99m</sup>Tc and <sup>123</sup>I-labeled radiopharmaceuticals using shielded syringes.","authors":"Yuto Nakamura, Narumi Yasuno","doi":"10.1007/s12194-024-00789-8","DOIUrl":null,"url":null,"abstract":"<p><p>This study investigates the feasibility of estimating the radioactivity of radiopharmaceuticals using shielded syringes. The radioactivities of <sup>99m</sup>Tc-MDP, <sup>99m</sup>Tc-HMDP, <sup>99m</sup>Tc-ECD, <sup>99m</sup>Tc-MAG<sub>3</sub>, and <sup>123</sup>I-IMP were measured using a dose calibrator. Correlation coefficients and regression equations were obtained from the radioactivity in the shielded and unshielded syringes. <sup>99m</sup>Tc-MDP was also measured for residual radioactivity after the administration. The correlation coefficients of <sup>99m</sup>Tc-MDP, <sup>99m</sup>Tc-HMDP, <sup>99m</sup>Tc-ECD, <sup>99m</sup>Tc-MAG<sub>3</sub>, and <sup>123</sup>I-IMP were r<sub>s</sub> = 0.9998, r<sub>s</sub> = 0.9997, r<sub>s</sub> = 0.9999, r<sub>s</sub> = 0.9998, and r<sub>s</sub> = 0.9888, respectively. The regression equations were y = 0.0364x + 0.0913, y = 0.0349x + 0.0273, y = 0.0343x - 0.0018, y = 0.0522x + 0.1215, and y = 0.0383x + 0.0058, respectively. The correlation coefficient for the residual radioactivity of <sup>99m</sup>Tc-MDP was r<sub>s</sub> = 0.9887 and the regression equation was y = 0.1505x + 0.0853. The radioactivity of <sup>99m</sup>Tc- and <sup>123</sup>I-labeled radiopharmaceuticals in shielded syringes was accurately measured. It was suggested that the measuring shielded syringes could provide an estimate of the actual radioactivity.</p>","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":" ","pages":"396-401"},"PeriodicalIF":1.7000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiological Physics and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12194-024-00789-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/22 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

Abstract

This study investigates the feasibility of estimating the radioactivity of radiopharmaceuticals using shielded syringes. The radioactivities of 99mTc-MDP, 99mTc-HMDP, 99mTc-ECD, 99mTc-MAG3, and 123I-IMP were measured using a dose calibrator. Correlation coefficients and regression equations were obtained from the radioactivity in the shielded and unshielded syringes. 99mTc-MDP was also measured for residual radioactivity after the administration. The correlation coefficients of 99mTc-MDP, 99mTc-HMDP, 99mTc-ECD, 99mTc-MAG3, and 123I-IMP were rs = 0.9998, rs = 0.9997, rs = 0.9999, rs = 0.9998, and rs = 0.9888, respectively. The regression equations were y = 0.0364x + 0.0913, y = 0.0349x + 0.0273, y = 0.0343x - 0.0018, y = 0.0522x + 0.1215, and y = 0.0383x + 0.0058, respectively. The correlation coefficient for the residual radioactivity of 99mTc-MDP was rs = 0.9887 and the regression equation was y = 0.1505x + 0.0853. The radioactivity of 99mTc- and 123I-labeled radiopharmaceuticals in shielded syringes was accurately measured. It was suggested that the measuring shielded syringes could provide an estimate of the actual radioactivity.

使用屏蔽注射器估算 99mTc 和 123I 标记放射性药物放射性的可行性研究。
本研究探讨了使用屏蔽注射器估算放射性药物放射性的可行性。使用剂量校准器测量了 99m锝-MDP、99m锝-HMDP、99m锝-ECD、99m锝-MAG3 和 123I-IMP 的放射性活度。根据屏蔽注射器和非屏蔽注射器中的放射性得出了相关系数和回归方程。此外,还测量了给药后 99mTc-MDP 的残余放射性。99mTc-MDP 、99mTc-HMDP、99mTc-ECD、99mTc-MAG3 和 123I-IMP 的相关系数分别为 rs = 0.9998、rs = 0.9997、rs = 0.9999、rs = 0.9998 和 rs = 0.9888。回归方程分别为 y = 0.0364x + 0.0913、y = 0.0349x + 0.0273、y = 0.0343x - 0.0018、y = 0.0522x + 0.1215 和 y = 0.0383x + 0.0058。99mTc-MDP 残余放射性的相关系数为 rs = 0.9887,回归方程为 y = 0.1505x + 0.0853。准确测量了屏蔽注射器中 99mTc 和 123I 标记放射性药物的放射性。测量结果表明,屏蔽注射器可提供实际放射性的估计值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Radiological Physics and Technology
Radiological Physics and Technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
3.00
自引率
12.50%
发文量
40
期刊介绍: The purpose of the journal Radiological Physics and Technology is to provide a forum for sharing new knowledge related to research and development in radiological science and technology, including medical physics and radiological technology in diagnostic radiology, nuclear medicine, and radiation therapy among many other radiological disciplines, as well as to contribute to progress and improvement in medical practice and patient health care.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信