Alliaxylines A–E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss

Abstract

A total of five new mexicanolides (1–5), namely alliaxylines A–E, together with two known limonoids 6 and 7, were isolated and identified from Dysoxylum alliaceum (Blume) Blume ex. A.Juss. (Meliaceae). The structures of these compounds were elucidated based on extensive spectroscopic analyses, including HR-ESI–MS, UV, IR, 1D, and 2D NMR, as well as theoretical stimulation of NMR shifts with the DP4 + algorithm. Consequently, this study aimed to examine cytotoxic activities of these compounds against MCF-7 and A549 cell lines. The results implied that compound 2 was the most potent against the two tested cells, with IC₅₀ values of 34.95 ± 0.21 and 44.39 ± 1.03 µM.

Graphical Abstract