Treatment activity of hydrogels loaded with metal–organic frameworks of bleomycin on hemangioma

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2024-03-08 DOI:10.1016/j.ica.2024.122009

Shengquan Wang , Lei Sun , Hongxia Gao , Wenpei Zhang

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Abstract

In the current paper, through utilizing two symmetrical pentacarboxylate ligands, namely, 3,5-di(2′,5′-dicarboxylphenyl)benzoic (H₅L₁) and 3,5-di(2′,4′ dicarboxylphenyl)benzoic acid (H₅L₂), two fresh Co(II)-basd coordination polymers (CPs), [Co₅(μ₃-H₂O)₂(L1)₂]·3DMA·4H₂O (1, DMA is N,N-dimethylacetamide) along with [Co₃(μ₃-OH)L2(H₂O)₃]·H₂O (2) have been synthesized under the conditions of solvothermal. With hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) as raw materials, HA/CMCS hydrogel was prepared by chemical synthesis and its internal microstructure was observed by scanning electron microscope. Using bleomycin as a drug model, we designed and synthesized two metallogel particle frameworks encapsulating bleomycin drugs and compared the effects of the two metallogel particle frameworks as drug carriers for delivering bleomycin drugs for the treatment of hemangiomas.

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博莱霉素金属有机框架水凝胶对血管瘤的治疗活性

本文利用两种对称的五羧酸配体，即 3,5-二（2′,5′-二羧基苯基）苯甲酸（H5L1）和 3,5-二（2′,4′-二羧基苯基）苯甲酸（H5L2）、在溶热条件下合成了两种新的 Co（II）基配位聚合物（CPs）：[Co5(μ3-H2O)2(L1)2]-3DMA-4H2O（1，DMA 为 N,N-二甲基乙酰胺）和[Co3(μ3-OH)L2(H2O)3]-H2O（2）。以透明质酸（HA）和羧甲基壳聚糖（CMCS）为原料，用化学合成法制备了HA/CMCS水凝胶，并用扫描电子显微镜观察了其内部微观结构。以博来霉素为药物模型，设计合成了两种包裹博来霉素药物的金属凝胶颗粒框架，并比较了两种金属凝胶颗粒框架作为药物载体输送博来霉素药物治疗血管瘤的效果。

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.