Quantitative MRI assessment of joint effusion using T2-relaxometry at 3 Tesla: a feasibility and reproducibility study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-11-01 Epub Date: 2024-03-21 DOI:10.1007/s00256-024-04652-0

Flora H P van Leeuwen, Beatrice Lena, Eline D P van Bergen, Janoah J van Klei, Merel A Timmer, Lize F D van Vulpen, Kathelijn Fischer, Pim A de Jong, Clemens Bos, Wouter Foppen

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Abstract

Objective: T2-relaxometry could differentiate between physiological and haemorrhagic joint effusion (≥ 5% blood) in vitro. Are quantitative T2-relaxation time measurements of synovial fluid feasible and reproducible in vivo in clinically bleed-free joints of men with haemophilia?

Materials and methods: In this cross-sectional study, we measured T2-relaxation times of synovial fluid in clinically bleed-free ankles, knees or elbows of men with severe haemophilia A using a T2-mapping sequence (duration ≤ 7 min) at 3 Tesla MRI. Manual and circular regions of interest (ROI) were drawn in the synovial fluid of each joint by two independent observers to measure T2-relaxation times. Measurement feasibility was expressed as the success rate of the measurements by both observers. The interobserver and intraobserver reproducibility of the measurements were evaluated by the intraclass correlation coefficient of absolute agreement (ICC) and the limits of agreement (LoA) from Bland Altman analysis.

Results: We evaluated 39 clinically bleed-free joints (11 ankles, 12 knees, 16 elbows) of 39 men (median age, 24 years; range 17-33) with severe haemophilia A. The success rate of the T2-measurements was ≥ 90%. Interobserver reliability was good to excellent (manual ROI: ICC = 0.92, 95% CI 0.76-0.97; circular ROI: ICC = 0.82, 95% CI 0.66-0.91) and interobserver agreement was adequate (manual ROI: LoA = 71 ms; circular ROI: LoA = 146 ms). Intraobserver reliability was good to excellent (manual ROI: ICC = 0.78, 95% CI - 0.06-0.94; circular RO: ICC = 0.99, 95% CI 0.98-0.99) and intraobserver agreement was good (manual ROI: LoA = 63 ms; circular ROI: LoA = 41 ms).

Conclusion: T2-relaxometry of synovial fluid in haemophilia patients is feasible with good interobserver and intraobserver reproducibility.

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在 3 特斯拉下使用 T2-松弛测量法对关节积液进行磁共振成像定量评估：一项可行性和可重复性研究。

目的：T2-松弛时间测定法可在体外区分生理性关节积液和出血性关节积液（血液含量≥5%）。在血友病男性患者的临床无出血关节中，对滑液的 T2-松弛时间进行定量测量是否可行且具有可重复性？在这项横断面研究中，我们使用 3 特斯拉核磁共振成像的 T2 映射序列（持续时间 ≤ 7 分钟）测量了严重血友病 A 男性患者临床无出血踝关节、膝关节或肘关节滑液的 T2 缓解时间。由两名独立观察者在每个关节的滑液中手动绘制圆形感兴趣区（ROI），以测量 T2 松弛时间。测量的可行性用两名观察者的测量成功率来表示。测量的观察者间和观察者内的再现性通过绝对一致的类内相关系数（ICC）和布兰德-阿尔特曼分析的一致界限（LoA）进行评估：我们对 39 名重度血友病 A 型男性患者（中位年龄 24 岁，17-33 岁不等）的 39 个临床无出血关节（11 个脚踝、12 个膝盖和 16 个肘关节）进行了评估。观察者之间的可靠性良好至极佳（手动 ROI：ICC = 0.92，95% CI 0.76-0.97；圆形 ROI：ICC = 0.82，95% CI 0.66-0.91），观察者之间的一致性良好（手动 ROI：LoA = 71 ms；圆形 ROI：LoA = 146 ms）。观察者内部的可靠性良好至极佳（手动 ROI：ICC = 0.78，95% CI = 0.66-0.91）：ICC = 0.78，95% CI - 0.06-0.94；圆形 ROI：ICC = 0.99，95% CI 0.98-0.99），观察者内部一致性良好（手动 ROI：LoA = 63 ms；圆形 ROI：LoA = 41 ms）：结论：血友病患者滑膜液的 T2-松弛测量是可行的，观察者之间和观察者内部具有良好的再现性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.