3-Dimensional Reconstruction From Histopathological Sections: A Systematic Review

IF 5.1 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Laboratory Investigation Pub Date : 2024-03-19 DOI:10.1016/j.labinv.2024.102049

Alexander Kurz , Heimo Müller , Jakob N. Kather , Lucas Schneider , Tabea-C. Bucher , Titus J. Brinker

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引用次数: 0

Abstract

Although pathological tissue analysis is typically performed on single 2-dimensional (2D) histologic reference slides, 3-dimensional (3D) reconstruction from a sequence of histologic sections could provide novel opportunities for spatial analysis of the extracted tissue. In this review, we analyze recent works published after 2018 and report information on the extracted tissue types, the section thickness, and the number of sections used for reconstruction. By analyzing the technological requirements for 3D reconstruction, we observe that software tools exist, both free and commercial, which include the functionality to perform 3D reconstruction from a sequence of histologic images. Through the analysis of the most recent works, we provide an overview of the workflows and tools that are currently used for 3D reconstruction from histologic sections and address points for future work, such as a missing common file format or computer-aided analysis of the reconstructed model.

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组织病理学切片的三维重建：系统回顾

病理组织分析通常是在单张二维（2D）组织学参考切片上进行的，而从组织学切片序列进行三维（3D）重建可为提取组织的空间分析提供新的机会。在这篇综述中，我们分析了 2018 年之后发表的最新作品，并报告了提取的组织类型、切片厚度和用于重建的切片数量等信息。通过分析三维重建的技术要求，我们发现目前已有免费和商业软件工具，包含从组织学图像序列执行三维重建的功能。通过对最新作品的分析，我们概述了目前用于组织学切片三维重建的工作流程和工具，并探讨了未来工作的要点，如缺失的通用文件格式或重建模型的计算机辅助分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Laboratory Investigation 医学-病理学

CiteScore

8.30

自引率

0.00%

发文量

125

审稿时长

2 months

期刊介绍： Laboratory Investigation is an international journal owned by the United States and Canadian Academy of Pathology. Laboratory Investigation offers prompt publication of high-quality original research in all biomedical disciplines relating to the understanding of human disease and the application of new methods to the diagnosis of disease. Both human and experimental studies are welcome.