Association of interleukin-17A and chemokine/vascular endothelial growth factor-induced angiogenesis in newly diagnosed patients with bladder cancer.

IF 2.9 4区医学 Q3 IMMUNOLOGY

BMC Immunology Pub Date : 2024-03-21 DOI:10.1186/s12865-024-00612-4

Ali Moadab, Mohammad Rafie Valizadeh, Alireza Nazari, Hossein Khorramdelazad

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引用次数: 0

Abstract

Background: The human interleukin-17 (IL-17) family comprises IL-17A to IL-17 F; their receptors are IL-17RA to IL-17RE. Evidence revealed that these cytokines can have a tumor-supportive or anti-tumor impact on human malignancies. The purpose of this study was to assess the expression of CXCR2, IL-17RA, and IL-17RC genes at the mRNA level as well as tissue and serum levels of IL-17A, vascular endothelial growth factor (VEGF), and transforming growth factor β (TGF-β) in patients with bladder cancer (BC) compared to control.

Results: This study showed that gene expression of IL-17RA, IL-17RC, and CXCR2 in the tumoral tissue of BC patients was significantly upregulated compared with normal tissue. The findings disclosed a significant difference in the serum and tissue concentrations of IL-17A, VEGF, and TGF-β between the patient and the control groups, as well as tumor and normal tissues.

Conclusion: This study reveals notable dysregulation of CXCR2, IL-17RA, and IL-17RC genes, alongside changes in IL-17A, VEGF, and TGF-β levels in patients with BC than in controls. These findings indicate their possible involvement in BC development and their potential as diagnostic and therapeutic targets.

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新诊断的膀胱癌患者中白细胞介素-17A与趋化因子/血管内皮生长因子诱导的血管生成有关。

背景：人类白细胞介素-17（IL-17）家族由 IL-17A 至 IL-17 F 组成，其受体为 IL-17RA 至 IL-17RE。有证据表明，这些细胞因子可对人类恶性肿瘤产生支持或抗肿瘤影响。本研究的目的是评估膀胱癌（BC）患者与对照组相比，CXCR2、IL-17RA 和 IL-17RC 基因在 mRNA 水平上的表达以及组织和血清中 IL-17A、血管内皮生长因子（VEGF）和转化生长因子 β（TGF-β）的水平：研究表明，与正常组织相比，膀胱癌患者肿瘤组织中 IL-17RA、IL-17RC 和 CXCR2 的基因表达明显上调。研究结果表明，IL-17A、血管内皮生长因子和 TGF-β 在患者组与对照组、肿瘤组织与正常组织之间的血清和组织浓度存在明显差异：本研究发现，与对照组相比，BC 患者的 CXCR2、IL-17RA 和 IL-17RC 基因明显失调，同时 IL-17A、VEGF 和 TGF-β 水平也发生了变化。这些发现表明，它们可能参与了 BC 的发展，并有可能成为诊断和治疗目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Immunology 医学-免疫学

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： BMC Immunology is an open access journal publishing original peer-reviewed research articles in molecular, cellular, tissue-level, organismal, functional, and developmental aspects of the immune system as well as clinical studies and animal models of human diseases.