Insights into the enigma of oral streptococci in carcinogenesis.

IF 8 1区 生物学 Q1 MICROBIOLOGY
Microbiology and Molecular Biology Reviews Pub Date : 2024-06-27 Epub Date: 2024-03-20 DOI:10.1128/mmbr.00095-23
Sangeetha Senthil Kumar, Michael D L Johnson, Justin E Wilson
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引用次数: 0

Abstract

SUMMARYThe genus Streptococcus consists of a taxonomically diverse group of Gram-positive bacteria that have earned significant scientific interest due to their physiological and pathogenic characteristics. Within the genus Streptococcus, viridans group streptococci (VGS) play a significant role in the oral ecosystem, constituting approximately 80% of the oral biofilm. Their primary role as pioneering colonizers in the oral cavity with multifaceted interactions like adherence, metabolic signaling, and quorum sensing contributes significantly to the complex dynamics of the oral biofilm, thus shaping oral health and disease outcomes. Perturbations in oral streptococci composition drive oral dysbiosis and therefore impact host-pathogen interactions, resulting in oral inflammation and representing VGS as an opportunistic pathogen. The association of oral streptococci in tumors across distant organs, spanning the esophagus, stomach, pancreas, and colon, illuminates a potential association between oral streptococci, inflammation, and tumorigenesis. This finding emphasizes the need for further investigations into the role of oral streptococci in mucosal homeostasis and their involvement in carcinogenesis. Hence, here, we review the significance of oral streptococci in biofilm dynamics and how the perturbation may impact mucosal immunopathogenesis in the context of cancer, with a vision of exploiting oral streptococci for cancer intervention and for the development of non-invasive cancer diagnosis.

洞察口腔链球菌致癌之谜。
摘要 链球菌属由分类学上多种多样的革兰氏阳性细菌组成,因其生理和致病特性而备受科学界关注。在链球菌属中,病毒群链球菌(VGS)在口腔生态系统中发挥着重要作用,约占口腔生物膜的 80%。它们是口腔中的先锋定殖菌,具有多方面的相互作用,如粘附、代谢信号转导和法定量感应,对口腔生物膜的复杂动态起着重要作用,从而影响口腔健康和疾病结果。口腔链球菌组成的紊乱会导致口腔菌群失调,从而影响宿主与病原体之间的相互作用,导致口腔炎症,并使 VGS 成为一种机会性病原体。口腔链球菌与食道、胃、胰腺和结肠等远处器官的肿瘤有关,这说明口腔链球菌、炎症和肿瘤发生之间存在潜在联系。这一发现强调了进一步研究口腔链球菌在粘膜平衡中的作用及其在致癌过程中的参与的必要性。因此,我们在此回顾了口腔链球菌在生物膜动态中的重要作用,以及在癌症背景下这种扰动如何影响粘膜免疫发病机制,以期利用口腔链球菌进行癌症干预和开发非侵入性癌症诊断。
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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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