Association of the ESR1 (rs9340799), OLR1 (rs3736234), LIPC (rs2070895), VDR (rs2228570), and CETP (rs708272) Polymorphisms With Risk of Coronary Artery Disease in Iranian Patients

IF 2.6 4区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Zahra Miri Karam, Abolfazl Yari, Atefeh Najmadini, Nima Norouzi Khorasani, Rezvan Attari, Saeideh Jafarinejad-Farsangi, Mohammad Ali Miri Karam, Hamid Najafipour, Kolsoum Saeidi
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引用次数: 0

Abstract

Background

Coronary artery disease (CAD) is a devastating illness and a leading cause of death worldwide, primarily caused by atherosclerosis resulting from a genetic-environmental interaction. This study aimed to investigate the relationship between the ESR1 (rs9340799), OLR1 (rs3736234), LIPC (rs2070895), VDR (rs2228570), and CETP (rs708272) polymorphisms, lipid profile parameters, and CAD risk in a southeast Iranian population.

Methods

A total of 400 subjects (200 CAD patients with hyperlipidemia and 200 healthy controls) were enrolled in this case–control study. Five selected polymorphisms were genotyped using the polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) technique.

Results

For all single nucleotide polymorphisms (SNPs), the population under study was in the Hardy–Weinberg equilibrium. The T-risk allele frequency of rs2228570 was associated with an increased risk of CAD. The TT and CT genotypes of rs2228570 had also been associated with the risk of CAD. Additionally, the TT genotype was associated with higher serum low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) levels. The GG genotype of the rs3736234 was associated with higher body mass index (BMI) and triglyceride (TG) levels, and the AA genotype of the rs708272 was associated with higher HDL-c levels. Based on these findings, we propose that the VDR (rs2228570) polymorphism was associated with serum HDL-c and LDL-c levels and may serve as potential risk factors for CAD within the Iranian population. Moreover, rs3736234 and rs708272 influence the concentrations of TG and HDL-c, respectively.

Conclusion

These findings provided insights into the complex interplay between genetic variations, cardiovascular risk, and lipid metabolism.

Abstract Image

Abstract Image

伊朗患者的 ESR1 (rs9340799)、OLR1 (rs3736234)、LIPC (rs2070895)、VDR (rs2228570) 和 CETP (rs708272) 多态性与冠状动脉疾病风险的关系。
背景:冠状动脉疾病(CAD)是一种破坏性疾病,也是全球死亡的主要原因,其主要原因是遗传与环境相互作用导致的动脉粥样硬化。本研究旨在调查伊朗东南部人群中 ESR1 (rs9340799)、OLR1 (rs3736234)、LIPC (rs2070895)、VDR (rs2228570) 和 CETP (rs708272) 多态性、血脂谱参数和 CAD 风险之间的关系:这项病例对照研究共招募了 400 名受试者(200 名患有高脂血症的 CAD 患者和 200 名健康对照者)。采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术对所选的五个多态性进行了基因分型:在所有单核苷酸多态性(SNPs)中,研究人群均处于哈代-温伯格平衡状态。rs2228570的T风险等位基因频率与CAD风险增加有关。rs2228570 的 TT 和 CT 基因型也与患 CAD 的风险有关。此外,TT 基因型与较高的血清低密度脂蛋白胆固醇(LDL-c)和高密度脂蛋白胆固醇(HDL-c)水平有关。rs3736234 的 GG 基因型与较高的体重指数(BMI)和甘油三酯(TG)水平相关,而 rs708272 的 AA 基因型与较高的 HDL-c 水平相关。基于这些发现,我们认为 VDR(rs2228570)多态性与血清高密度脂蛋白胆固醇(HDL-c)和低密度脂蛋白胆固醇(LDL-c)水平有关,并可能成为伊朗人群患 CAD 的潜在风险因素。此外,rs3736234 和 rs708272 分别影响 TG 和 HDL-c 的浓度:这些研究结果有助于深入了解遗传变异、心血管风险和脂质代谢之间复杂的相互作用。
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来源期刊
Journal of Clinical Laboratory Analysis
Journal of Clinical Laboratory Analysis 医学-医学实验技术
CiteScore
5.60
自引率
7.40%
发文量
584
审稿时长
6-12 weeks
期刊介绍: Journal of Clinical Laboratory Analysis publishes original articles on newly developing modes of technology and laboratory assays, with emphasis on their application in current and future clinical laboratory testing. This includes reports from the following fields: immunochemistry and toxicology, hematology and hematopathology, immunopathology, molecular diagnostics, microbiology, genetic testing, immunohematology, and clinical chemistry.
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