Beneficial effects of cannabidiol from Cannabis

IF 2.3 3区农林科学 Q3 FOOD SCIENCE & TECHNOLOGY

Applied Biological Chemistry Pub Date : 2024-03-19 DOI:10.1186/s13765-024-00867-w

Sullim Lee, Yunjeong Lee, Yunseo Kim, Hyunji Kim, Haerim Rhyu, Kyoungmi Yoon, Chang-Dae Lee, Sanghyun Lee

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Abstract

Cannabis, traditionally used for recreation due to psychoactive compounds in its leaves, flowers, and seeds, has not been thoroughly explored for potential therapeutic benefits. Δ9-trans-Tetrahydrocannabinol, a key cannabinoid in cannabis, causes hallucinogenic effects and delirium symptoms. In contrast, cannabidiol (CBD) does not induce hallucinations and has shown effectiveness in treating symptoms of various rare, incurable diseases. Cannabis exhibits neuroprotective, anti-inflammatory, anti-thrombotic, anti-bacterial, analgesic, and antiepileptic properties, recently attracting more attention. This review aims to summarize comprehensively the impact of cannabis on human health, focusing on endocannabinoids and their receptors. It also delves into recent CBD research advancements, highlighting the compound’s potential medical applications. Overall, this paper provides valuable insights into the prospective development of medical cannabis, with a particular emphasis on CBD.

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大麻中的大麻二酚的益处

由于大麻叶、花和种子中含有精神活性化合物，大麻传统上被用于娱乐，但其潜在的治疗功效尚未得到深入研究。Δ9-反式四氢大麻酚是大麻中的一种主要大麻素，会产生致幻效果和谵妄症状。相比之下，大麻二酚（CBD）不会引起幻觉，而且在治疗各种罕见、无法治愈的疾病症状方面显示出了疗效。大麻具有神经保护、抗炎、抗血栓、抗菌、镇痛和抗癫痫等特性，最近受到越来越多的关注。本综述旨在全面总结大麻对人类健康的影响，重点关注内源性大麻素及其受体。它还深入探讨了 CBD 的最新研究进展，强调了该化合物的潜在医疗应用。总之，本文为医用大麻的发展前景提供了宝贵的见解，并特别强调了 CBD。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Biological Chemistry Chemistry-Organic Chemistry

CiteScore

5.40

自引率

6.20%

发文量

审稿时长

20 weeks

期刊介绍： Applied Biological Chemistry aims to promote the interchange and dissemination of scientific data among researchers in the field of agricultural and biological chemistry. The journal covers biochemistry and molecular biology, medical and biomaterial science, food science, and environmental science as applied to multidisciplinary agriculture.