A Snapshot of Biomarkers in Psoriasis.

Krushna Abhale, Addepalli Veeranjaneyulu, Shivani Desai
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Abstract

A persistent long-standing, inflammatory skin condition that is brought on by a variety of factors is psoriasis. It is distinguished by itchy, scaly, reddish plaques, particularly on areas of the body that are frequently chafed, including the extensor sites of the limbs. Recent developments in molecular-targeted therapy that use biologics or small-molecule inhibitors can effectively cure even the worst psoriatic indications. The outstanding clinical outcomes of treatment help to clarify the disease's detrimental consequences on quality of life. Biomarkers that identify deep remission are essential for developing uniform treatment plans. Blood protein markers such as AMPs that are consistently quantifiable can be very helpful in routine clinical practice. The metabolic pathways involve biomarkers that can not only help diagnose psoriasis in a clinical setting but also indicate its severity based on the levels present in the body. Machine learning and AI have made a diagnosis of the expression of genes as biomarkers more accessible. In this article, biomarkers, as well as their key role in psoriasis, are discussed.

牛皮癣生物标志物快照。
银屑病是一种由多种因素引起的长期顽固的炎症性皮肤病。其特征是瘙痒、脱屑、淡红色斑块,尤其是在身体经常摩擦的部位,包括四肢伸展部位。分子靶向疗法的最新进展是使用生物制剂或小分子抑制剂,即使是最严重的银屑病适应症也能有效治愈。出色的临床治疗效果有助于澄清该疾病对生活质量造成的不利影响。确定深度缓解的生物标志物对于制定统一的治疗方案至关重要。可持续量化的血液蛋白标记物(如 AMPs)对常规临床实践非常有帮助。代谢途径涉及的生物标志物不仅有助于临床诊断银屑病,还能根据体内存在的水平显示银屑病的严重程度。机器学习和人工智能使作为生物标志物的基因表达诊断变得更加容易。本文将讨论生物标志物及其在银屑病中的关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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