The Future of Checkpoint Inhibitors in Uveal Melanoma: A Narrative Review.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-05-01 Epub Date: 2024-03-18 DOI:10.1007/s40123-024-00913-2

Jinyu Wang, Zehua Li, Hongbo Yin

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引用次数: 0

Abstract

Introduction: Immune checkpoint inhibitors have made tremendous progress over the last decade in the treatment of cutaneous melanoma, but their application in uveal melanoma treatment is less successful, owing in part to the immunological privilege of the eye and the liver, the most frequent site of metastasis. Nevertheless, the therapeutic outcomes reported currently are less pessimistic.

Methods: In this review, we provide an overview of recent studies of immune checkpoint inhibitors in uveal melanoma and its metastasis and classify studies in this field into three groups: monotherapy of immune checkpoint inhibitors, dual-agent immune checkpoint inhibitors, and immune checkpoint inhibitors combined with other systemic or regional therapies.

Results: Briefly, monotherapy with immune checkpoint inhibitors performed poorly. Dual-agent immune checkpoint inhibitors had slightly better outcomes than traditional treatments, especially in specific patient populations. As for the combination therapy, the combination with other systemic therapies did not show superiority over dual-agent immune checkpoint inhibitors, but combination with hepatic regional therapies was quite promising. Moreover, research on emerging checkpoints is currently limited to the stage of mechanistic studies.

Conclusion: We propose that immune checkpoint inhibitors remain alternative treatments for patients with uveal melanoma, but factors such as cost-effectiveness should also be taken into account. The combination therapy with immune checkpoint inhibitors deserves to be further explored.

Abstract Image

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检查点抑制剂在葡萄膜黑色素瘤中的未来：叙述性综述》（The Future of Checkpoint Inhibitors in Uveal Melanoma: A Narrative Review.

导言：过去十年来，免疫检查点抑制剂在治疗皮肤黑色素瘤方面取得了巨大进展，但在葡萄膜黑色素瘤治疗中的应用却不太成功，部分原因是眼部和肝脏（最常见的转移部位）具有免疫特权。尽管如此，目前报道的治疗结果并不那么悲观：在这篇综述中，我们概述了近期关于免疫检查点抑制剂治疗葡萄膜黑色素瘤及其转移的研究，并将该领域的研究分为三类：免疫检查点抑制剂单药治疗、双剂免疫检查点抑制剂以及免疫检查点抑制剂联合其他系统或区域疗法：结果：简而言之，免疫检查点抑制剂的单一疗法效果不佳。双药免疫检查点抑制剂的疗效略好于传统疗法，尤其是在特定患者群体中。至于联合疗法，与其他系统疗法的联合并没有显示出优于双药免疫检查点抑制剂，但与肝区疗法的联合却很有前景。此外，对新兴检查点的研究目前仅限于机理研究阶段：我们建议，免疫检查点抑制剂仍是葡萄膜黑色素瘤患者的替代疗法，但也应考虑成本效益等因素。免疫检查点抑制剂的联合疗法值得进一步探索。

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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