Association between PEMT rs7946 and blood pressure levels in Chinese adolescents.

IF 1.2 4区医学 Q4 PERIPHERAL VASCULAR DISEASE

Blood Pressure Monitoring Pub Date : 2024-08-01 Epub Date: 2024-03-18 DOI:10.1097/MBP.0000000000000703

Guo Ming Su, Qi Wei Guo, Yi Lin Shen, Jia Jing Cai, Xu Chen, Jia Lin, Ding Zhi Fang

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引用次数: 0

Abstract

Objectives: This study was to explore blood pressure levels in Chinese adolescents with different genotypes of phosphatidylethanolamine N-methyltransferase (PEMT) gene ( PEMT ) rs7946, as well as effects of dietary intake on blood pressure levels with different genders and different genotypes of PEMT rs7946.

Methods: PEMT rs7946 genotypes were identified by PCR-restriction fragment length polymorphism and verified by DNA sequencing. Blood pressure was measured using a standard mercury sphygmomanometer. Dietary intakes were analyzed based on a 3-day diet diary, and dietary components were calculated using computer software.

Results: A total of 721 high school students (314 males and 407 females) at the age of 16.86 ± 0.59 years were included. The A allele carriers of PEMT rs7946 had increased levels of SBP, DBP, mean arterial pressure (MAP) and pulse pressure (PP) than the GG homozygotes in the female subjects. There were significant interactions between PEMT rs7946 and gender on SBP and MAP levels, regardless of whether an unadjusted or adjusted model was used. When dietary intake was taken into account, fat intake was positively associated with SBP and PP in the male GG homozygotes, while protein intake was positively associated with PP in the female A allele carriers of PEMT rs7946.

Conclusion: This study suggests that PEMT rs7946 is significantly associated with blood pressure levels in human being. There might be interactions among PEMT rs7946, gender, and dietary intake on blood pressure levels in the adolescent population.

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中国青少年 PEMT rs7946 与血压水平的关系。

研究目的本研究旨在探讨磷脂酰乙醇胺N-甲基转移酶（PEMT）基因（PEMT）rs7946不同基因型中国青少年的血压水平，以及膳食摄入对不同性别、不同PEMT rs7946基因型青少年血压水平的影响：方法：通过 PCR-限制性片段长度多态性鉴定 PEMT rs7946 基因型，并通过 DNA 测序验证。使用标准水银血压计测量血压。根据 3 天饮食日记分析膳食摄入量，并使用计算机软件计算膳食成分：结果：共纳入 721 名高中生（男 314 人，女 407 人），年龄为 16.86 ± 0.59 岁。在女性受试者中，PEMT rs7946 的 A 等位基因携带者的 SBP、DBP、平均动脉压 (MAP) 和脉压 (PP) 水平均高于 GG 等位基因携带者。无论使用未调整模型还是调整模型，PEMT rs7946 与性别之间在 SBP 和 MAP 水平上都存在明显的交互作用。当考虑到饮食摄入量时，男性 GG 同源基因携带者的脂肪摄入量与 SBP 和 PP 呈正相关，而女性 PEMT rs7946 的 A 等位基因携带者的蛋白质摄入量与 PP 呈正相关：本研究表明，PEMT rs7946 与人类血压水平有显著相关性。结论：本研究表明，PEMT rs7946 与人类的血压水平明显相关，在青少年人群中，PEMT rs7946、性别和膳食摄入量可能会对血压水平产生相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood Pressure Monitoring 医学-外周血管病

CiteScore

2.00

自引率

7.70%

发文量

110

审稿时长

>12 weeks

期刊介绍： Blood Pressure Monitoring is devoted to original research in blood pressure measurement and blood pressure variability. It includes device technology, analytical methodology of blood pressure over time and its variability, clinical trials - including, but not limited to, pharmacology - involving blood pressure monitoring, blood pressure reactivity, patient evaluation, and outcomes and effectiveness research. This innovative journal contains papers dealing with all aspects of manual, automated, and ambulatory monitoring. Basic and clinical science papers are considered although the emphasis is on clinical medicine. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.