Effects of Outdoor Grown the Royal Sun Medicinal Mushroom Agaricus brasiliensis KA21 (Agaricomycetes) Fruit Body on Canine Malassezia Dermatitis

IF 1.4 4区生物学 Q4 MYCOLOGY

International journal of medicinal mushrooms Pub Date : 2024-03-01 DOI:10.1615/intjmedmushrooms.2024053187

Akitomo Motoi, Katsuya Tajima, Masuro Motoi, Katsuaki Nishihara, Daisuke Yamanaka, Ken-ichi Ishibashi, Naohito Ohno, Yoshiyuki Adachi

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引用次数: 0

Abstract

Brazil-grown outdoor-cultivated Agaricus brasiliensis KA21 fruit body (KA21) significantly increases the production of serum anti-beta-glucan antibody. Therefore, KA21 ingestion may be useful for the prevention and alleviation of fungal infections. This study aimed to determine the effects of KA21 in fungal infections in animals. KA21 was administered to nine dogs infected with Malassezia. Notably, the anti-beta-glucan antibody titer remained unchanged or tended to decrease in the oral steroid arm, whereas in the non-steroid arm, antibody titer increased in almost all animals after KA21 ingestion. Dogs showing improved clinical symptoms exhibited increased anti-beta-glucan antibody titers. The results of this study suggest that KA21 ingestion may alleviate the symptoms of Malassezia, and other fungal infections and that continuous ingestion may help prolong recurrence-free intervals. Additionally, the ingestion of KA21 during oral steroid dosage reduction or discontinuation may enable smoother steroid withdrawal.

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室外生长的皇家太阳药用蘑菇 Agaricus brasiliensis KA21（姬松茸）子实体对犬马拉色菌皮炎的影响

巴西种植的室外栽培姬松茸 KA21 子实体（KA21）能显著增加血清抗β-葡聚糖抗体的产生。因此，摄入 KA21 可能有助于预防和缓解真菌感染。本研究旨在确定 KA21 对动物真菌感染的影响。研究人员给 9 只感染马拉色菌的狗注射了 KA21。值得注意的是，在口服类固醇组中，抗β-葡聚糖抗体滴度保持不变或呈下降趋势，而在非类固醇组中，几乎所有动物在摄入 KA21 后抗体滴度都有所上升。临床症状得到改善的狗表现出抗β-葡聚糖抗体滴度升高。本研究结果表明，摄入 KA21 可减轻马拉色菌和其他真菌感染的症状，持续摄入 KA21 可能有助于延长无复发间隔期。此外，在口服类固醇剂量减少或停药期间摄入 KA21 可能会使类固醇停药过程更加顺利。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of medicinal mushrooms 医学-药学

CiteScore

2.60

自引率

16.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.