Associations of HIV and prevalent type 2 diabetes mellitus in the context of obesity in South Africa.

Itai M Magodoro, Alison C castle, Ndumiso Tshuma, Julia H. Goedecke, Ronel Sewpaul, Justen Manasa, Jennifer Manne-Goehler, Ntobeko AB Ntusi, Mark J Siedner
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Abstract

It is unclear how rising obesity among people with HIV (PWH) in sub-Saharan Africa (SSA) impacts their risk of type 2 diabetes mellitus (diabetes). Using a South African national cross-sectional sample of adult PWH and their peers without HIV (PWOH), we examined the associations between HIV and prevalent diabetes across the spectrum of body mass index (BMI), waist circumference (WC) and waist-to-height ratio (WtHR). Analyses were sex stratified, and adjusted for age, sociodemographic and behavioral factors. The prevalence of diabetes among males was similar between PWH and PWOH, overall and at all levels of adiposity. In contrast, overall diabetes prevalence was higher among female PWOH than female PWH. However, there also were differences according to adiposity such that, compared to female PWOH, relative diabetes prevalence in female PWH was reduced with obesity but accentuated with leanness. These differences in the relationship between adiposity and diabetes by HIV serostatus call for better mechanistic understanding of sex-specific adipose tissue biology in HIV in South Africa, and possibly in other HIV endemic settings in SSA.
南非肥胖背景下艾滋病毒与 2 型糖尿病流行的关联。
目前还不清楚撒哈拉以南非洲地区(SSA)艾滋病病毒感染者(PWH)肥胖症的增加如何影响他们罹患 2 型糖尿病(糖尿病)的风险。通过对南非全国成年艾滋病感染者及其未感染艾滋病的同龄人(PWOH)进行横断面抽样调查,我们研究了艾滋病与糖尿病发病率之间在体重指数(BMI)、腰围(WC)和腰围身高比(WtHR)等方面的关系。分析按性别分层,并对年龄、社会人口和行为因素进行了调整。总体而言,在所有脂肪水平上,肥胖者和肥胖者之间的男性糖尿病患病率相似。相比之下,女性肥胖者的糖尿病患病率高于女性肥胖者。不过,不同的肥胖程度也存在差异,例如,与女性肥胖者相比,女性肥胖者的相对糖尿病患病率随着肥胖程度的增加而降低,但随着瘦削程度的增加而升高。根据艾滋病毒血清状况的不同,脂肪含量与糖尿病之间的关系也存在差异,这就要求我们从机制上更好地了解南非以及撒南非洲其他艾滋病毒流行地区的艾滋病毒感染者的性别特异性脂肪组织生物学特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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