Neutrophil Percentage as a Potential Biomarker of Acute Kidney Injury Risk and Short-Term Prognosis in Patients with Acute Myocardial Infarction in the Elderly

IF 3.6 3区医学

Clinical Interventions in Aging Pub Date : 2024-03-18 DOI:10.2147/cia.s455588

Qianwen Chen, Qingqing Gu, Anwen Yin, Dabei Cai, Tingting Xiao, Yu Wang, Yuan Ji, Qingjie Wang, Jun Wei, Ling Sun

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引用次数: 0

Abstract

Objective: This study aimed to explore the association of preoperative neutrophil percentage (NEUT%) with the risk of acute kidney injury (AKI) in patients with acute myocardial infarction (AMI) having undergone coronary interventional therapy.
Methods: A single-center, retrospective and observational study was conducted. From December 2012 to June 2021, patients with AMI were enrolled and divided into AKI group and non-AKI group. The NEUT% in the two groups was compared. The association between NEUT% with the risk of post-AMI AKI was analyzed by univariate and multivariable logistic regression. Kaplan-Meier survival curve was drawn to evaluate the prognostic ability of NEUT% for short-term all-cause death following AMI.
Results: A total of 3001 consecutive patients were enrolled with an average age of 64.38 years. AKI occurred in 327 (10.9%) patients. The NEUT% was higher in the AKI group than in the non-AKI group ([76.65± 11.43]% versus [73.22± 11.83]%, P< 0.001). NEUT% was also identified as an independent risk factor for AKI in AMI patients after adjustment (OR=1.021, 95% CI: 1.010– 1.033, P < 0.001). Compared with those at the lowest quartile of NEUT%, the patients at quartiles 2– 4 had a higher risk of AKI (P for trend = 0.003). The odds of AKI increased by 29.0% as NEUT% increased by 1 standard deviation (OR=1.290, 95% CI: 1.087– 1.531, P = 0.004). After a median of 35 days follow-up, 93 patients died. Patients with a higher NEUT% presented a higher risk of all-cause death after AMI (Log rank: χ² =24.753, P< 0.001).
Conclusion: In AMI patients, the peripheral blood NEUT% was positively associated with the odds of AKI and short-term all-cause mortality. NEUT% may provide physicians with more information about disease development and prognosis.

Keywords: neutrophil percentage, acute kidney injury, acute myocardial infarction

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作为老年急性心肌梗死患者急性肾损伤风险和短期预后潜在生物标志物的中性粒细胞百分比

研究目的本研究旨在探讨接受冠状动脉介入治疗的急性心肌梗死（AMI）患者术前中性粒细胞百分比（NEUT%）与急性肾损伤（AKI）风险的关系：进行了一项单中心、回顾性和观察性研究。2012年12月至2021年6月，研究人员招募了AMI患者，并将其分为AKI组和非AKI组。比较了两组患者的 NEUT%。通过单变量和多变量逻辑回归分析了NEUT%与AMI后AKI风险之间的关系。绘制了Kaplan-Meier生存曲线，以评估NEUT%对AMI后短期全因死亡的预后能力：共登记了 3001 名连续患者，平均年龄为 64.38 岁。327例（10.9%）患者发生了AKI。AKI组的NEUT%高于非AKI组（[76.65± 11.43]%对[73.22± 11.83]%，P< 0.001）。经调整后，NEUT%也被确定为AMI患者发生AKI的独立危险因素（OR=1.021，95% CI：1.010- 1.033，P< 0.001）。与NEUT%最低四分位数的患者相比，2-4分位数的患者发生AKI的风险更高（趋势P=0.003）。当NEUT%增加1个标准差时，发生AKI的几率增加29.0%（OR=1.290，95% CI：1.087- 1.531，P=0.004）。中位随访 35 天后，93 名患者死亡。NEUT%越高的患者在急性心肌梗死后全因死亡的风险越高（对数秩：χ2 =24.753，P< 0.001）：AMI患者外周血NEUT%与AKI和短期全因死亡率呈正相关。关键词：中性粒细胞百分比急性肾损伤急性心肌梗死

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.20

自引率

2.80%

发文量

193

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.