Magnetic tweezers in cell mechanics.

4区 生物学 Q3 Biochemistry, Genetics and Molecular Biology
Methods in enzymology Pub Date : 2024-01-01 Epub Date: 2024-01-05 DOI:10.1016/bs.mie.2023.12.007
Claudia Tanja Mierke
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引用次数: 0

Abstract

The chapter provides an overview of the applications of magnetic tweezers in living cells. It discusses the advantages and disadvantages of magnetic tweezers technology with a focus on individual magnetic tweezers configurations, such as electromagnetic tweezers. Solutions to the disadvantages identified are also outlined. The specific role of magnetic tweezers in the field of mechanobiology, such as mechanosensitivity, mechano-allostery and mechanotransduction are also emphasized. The specific usage of magnetic tweezers in mechanically probing cells via specific cell surface receptors, such as mechanosensitive channels is discussed and why mechanical probing has revealed the opening and closing of the channels. Finally, the future direction of magnetic tweezers is presented.

细胞力学中的磁镊。
本章概述了磁镊在活细胞中的应用。它讨论了磁镊技术的优缺点,重点是个别磁镊配置,如电磁镊。此外,还概述了解决所发现缺点的方法。此外,还强调了磁镊在机械生物学领域的具体作用,如机械敏感性、机械装配和机械传导。此外,还讨论了磁镊在通过特定细胞表面受体(如机械敏感通道)对细胞进行机械探测方面的具体用途,以及机械探测揭示通道开闭的原因。最后,介绍了磁镊的未来发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Methods in enzymology
Methods in enzymology 生物-生化研究方法
CiteScore
2.90
自引率
0.00%
发文量
308
审稿时长
3-6 weeks
期刊介绍: The critically acclaimed laboratory standard for almost 50 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 500 volumes the series contains much material still relevant today and is truly an essential publication for researchers in all fields of life sciences, including microbiology, biochemistry, cancer research and genetics-just to name a few. Five of the 2013 Nobel Laureates have edited or contributed to volumes of MIE.
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