Clinical implication of neck dissection for metastatic lymph nodes originating from non-head and neck regions.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-02-01 Epub Date: 2024-03-16 DOI:10.1080/00016489.2024.2327406

Min Ji Kim, So Hee Kang, MinSu Kwon, Young Ho Jung, Seung-Ho Choi, Soon Yuhl Nam, Yoon Se Lee

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引用次数: 0

Abstract

Background: Cervical lymph node metastasis (CLNM) from remote primary sites is rare in head and neck cancer. The efficacy of neck dissection is still being investigated for therapeutic benefits of local management in oligometastasis from non-head and neck cancer.

Objectives: To evaluate the clinical efficacy of neck dissection (ND) in CLNM from distant primary cancers and identify factors contributing to improved survival.

Materials and methods: This retrospective case-control study enrolled patients who underwent ND for CLNM from distant primary cancer at Asan Medical Centre between January 2010 and December 2020. We analysed overall survival and association between clinical covariate and survival.

Results: The study included 31 (14 males, 17 females) among 114 patients. Ovarian cancer was the most common primary malignancy (32.3%). Patients with fewer than three metastatic lymph nodes, without extranodal extension and with adjuvant therapy after surgery had better survival rates.

Conclusion and significance: In patients with CLNM from a distant primary cancer, ND is beneficial as local treatment. And adequate selection of patients for ND is pivotal to improve prognosis.

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对来自非头颈部的转移性淋巴结进行颈部清扫的临床意义。

背景：在头颈部癌症中，来自远处原发部位的颈淋巴结转移（CLNM）非常罕见。目前仍在研究颈部清扫术对非头颈部癌症的少见转移灶进行局部治疗的疗效：评估颈部切除术（ND）对来自远处原发癌的头颈部肿瘤的临床疗效，并确定提高生存率的因素：这项回顾性病例对照研究招募了2010年1月至2020年12月期间在牙山医疗中心接受ND治疗的远处原发癌CLNM患者。我们分析了总生存率以及临床协变量与生存率之间的关系：研究共纳入 114 名患者中的 31 人（14 名男性，17 名女性）。卵巢癌是最常见的原发性恶性肿瘤（32.3%）。转移淋巴结少于三个、无结节外扩展、术后接受辅助治疗的患者生存率更高：对于来自远处原发癌的CLNM患者，ND作为局部治疗是有益的。结论：对于来自远处原发癌的 CLNM 患者，ND 是一种有益的局部治疗方法，而对 ND 患者的适当选择是改善预后的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.