Targeting Strategies for Site-Specific mRNA Delivery

IF 4 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Bioconjugate Chemistry Bioconjugate Pub Date : 2024-03-16 DOI:10.1021/acs.bioconjchem.4c00038

Jiaxing Di, Pei Huang* and Xiaoyuan Chen*,

引用次数: 0

Abstract

mRNA therapeutics hold great promise for disease treatment, yet a key challenge lies in achieving site-specific mRNA delivery to maximize therapeutic efficacy while minimizing off-target side effects. This viewpoint delves into multiple complementary targeting strategies to achieve precise site-specific mRNA delivery, covering topics of administration routes, passive targeting, and active targeting. It highlights the critical importance of rationally designed nanocarriers for obtaining desired therapeutic effects and accelerating the clinical translation of mRNA therapeutics.

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定点 mRNA 运送的靶向策略。

mRNA 疗法在疾病治疗方面大有可为，但关键的挑战在于如何实现特定位点 mRNA 递送，以最大限度地提高疗效，同时最大限度地减少脱靶副作用。这一观点深入探讨了多种互补的靶向策略，以实现精确的特定位点 mRNA 递送，涵盖了给药途径、被动靶向和主动靶向等主题。它强调了合理设计纳米载体对于获得理想疗效和加速 mRNA 疗法临床转化的至关重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioconjugate Chemistry Bioconjugate 生物-化学综合

CiteScore

9.00

自引率

2.10%

发文量

236

审稿时长

1.4 months

期刊介绍： Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.