Heterogeneity of outcome measures in depression trials and the relevance of the content of outcome measures to patients: a systematic review.

IF 30.8 1区医学 Q1 PSYCHIATRY

Lancet Psychiatry Pub Date : 2024-04-01 DOI:10.1016/S2215-0366(23)00438-8

Christopher Veal, Anneka Tomlinson, Andrea Cipriani, Samuel Bulteau, Chantal Henry, Chlöé Müh, Suzanne Touboul, Nikki De Waal, Hana Levy-Soussan, Toshi A Furukawa, Eiko I Fried, Viet-Thi Tran, Astrid Chevance

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Abstract

Research waste occurs when randomised controlled trial (RCT) outcomes are heterogeneous or overlook domains that matter to patients (eg, relating to symptoms or functions). In this systematic review, we reviewed the outcome measures used in 450 RCTs of adult unipolar and bipolar depression registered between 2018 and 2022 and identified 388 different measures. 40% of the RCTs used the same measure (Hamilton Depression Rating Scale [HAMD]). Patients and clinicians matched each item within the 25 most frequently used measures with 80 previously identified domains of depression that matter to patients. Seven (9%) domains were not covered by the 25 most frequently used outcome measures (eg, mental pain and irritability). The HAMD covered a maximum of 47 (59%) of the 80 domains that matter to patients. An interim solution to facilitate evidence synthesis before a core outcome set is developed would be to use the most common measures and choose complementary scales to optimise domain coverage. TRANSLATIONS: For the French and Dutch translations of the abstract see Supplementary Materials section.

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抑郁症试验中结果测量的异质性以及结果测量内容与患者的相关性：系统综述。

当随机对照试验（RCT）结果不一致或忽略了对患者重要的领域（如与症状或功能相关）时，就会出现研究浪费。在这篇系统性综述中，我们回顾了2018年至2022年间登记的450项成人单相和双相抑郁症RCT中使用的结果测量方法，并确定了388种不同的测量方法。40%的RCT使用了相同的测量方法（汉密尔顿抑郁评定量表[HAMD]）。患者和临床医生将 25 种最常用的测量方法中的每个项目与之前确定的 80 个与患者息息相关的抑郁领域相匹配。25种最常用的结果测量法未涵盖7个领域（9%）（如精神痛苦和易怒）。HAMD 最多涵盖了患者关注的 80 个领域中的 47 个（59%）。在制定核心结果集之前，促进证据综合的临时解决方案是使用最常用的测量方法并选择补充量表，以优化领域覆盖。翻译：摘要的法文和荷兰文译文见补充材料部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lancet Psychiatry PSYCHIATRY-

CiteScore

58.30

自引率

0.90%

发文量

期刊介绍： The Lancet Psychiatry is a globally renowned and trusted resource for groundbreaking research in the field of psychiatry. We specialize in publishing original studies that contribute to transforming and shedding light on important aspects of psychiatric practice. Our comprehensive coverage extends to diverse topics including psychopharmacology, psychotherapy, and psychosocial approaches that address psychiatric disorders throughout the lifespan. We aim to channel innovative treatments and examine the biological research that forms the foundation of such advancements. Our journal also explores novel service delivery methods and promotes fresh perspectives on mental illness, emphasizing the significant contributions of social psychiatry.

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