Clinical effectiveness of pit and fissure sealants in primary and permanent teeth of children and adolescents: an umbrella review.

IF 2.3 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

European Archives of Paediatric Dentistry Pub Date : 2024-06-01 Epub Date: 2024-03-15 DOI:10.1007/s40368-024-00876-9

S Amend, C Boutsiouki, J Winter, D Kloukos, R Frankenberger, N Krämer

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引用次数: 0

Abstract

Purpose: This umbrella review aimed to critically appraise the evidence published in systematic reviews (SRs) on the clinical effectiveness of sealants compared with each other/the non-use in primary/permanent teeth of children and adolescents with at least 12-month follow-up.

Methods: A systematic literature search on 4 electronic databases was conducted up to January 18th, 2023. Following handsearching, two review authors independently screened retrieved articles, extracted data, and assessed the risk of bias (RoB) using the risk of bias in systematic reviews (ROBIS) tool. Based on a citation matrix, the overlap was interpreted by the corrected covered area (CCA).

Results: Of 239 retrieved records, 7 SRs met the eligibility criteria with a moderate overlap among them (CCA = 7.4%). For primary molars, in 1120 1.5- to 8-year-old children, data on the clinical effectiveness of sealants were inconclusive. For permanent molars, 3 SRs found a significant caries risk reduction for sealants versus non-use (≤ 36-month follow-up). There was insufficient evidence to proof superiority of sealants over fluoride varnish for caries prevention (3 SRs), and to rank sealant materials according to the best clinical effectiveness in permanent molars. One study was rated at low and 6 at high RoB, which did not allow for a valid quantitative synthesis.

Conclusion: Considering the limitations of this umbrella review, sealants are more effective for caries prevention in children's permanent molars compared to no treatment. Future well-implemented RCTs are needed to draw reliable conclusions on the clinical effectiveness of sealants in primary and permanent teeth of children and adolescents.

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儿童和青少年乳恒牙窝沟封闭剂的临床疗效：综述。

目的：本综述旨在批判性地评估系统综述（SR）中发表的证据，这些证据涉及在儿童和青少年的基牙/恒牙中使用封闭剂与不使用封闭剂之间的临床效果比较，并进行至少 12 个月的随访：截至 2023 年 1 月 18 日，在 4 个电子数据库中进行了系统性文献检索。手工检索后，两位综述作者独立筛选检索到的文章、提取数据，并使用系统综述偏倚风险（ROBIS）工具评估偏倚风险（RoB）。根据引文矩阵，用校正覆盖面积（CCA）解释重叠情况：结果：在检索到的 239 条记录中，有 7 条符合资格标准，其中有中度重叠（CCA = 7.4%）。在 1120 名 1.5 至 8 岁儿童的初级臼齿中，有关封闭剂临床效果的数据尚无定论。对于恒磨牙，3 份研究报告发现，封闭剂与不使用封闭剂相比可显著降低龋齿风险（≤ 36 个月的随访）。没有足够证据证明封闭剂在预防龋齿方面优于氟化物清漆（3 项研究报告），也没有足够证据证明封闭剂材料在恒磨牙中的最佳临床效果。一项研究被评为低 RoB，6 项被评为高 RoB，因此无法进行有效的定量综合：考虑到本综述的局限性，封闭剂对预防儿童恒磨牙龋齿比不治疗更有效。今后需要进行实施良好的研究性试验，才能就封闭剂对儿童和青少年恒牙的临床效果得出可靠的结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Paediatric Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.40

自引率

9.10%

发文量

期刊介绍： The aim and scope of European Archives of Paediatric Dentistry (EAPD) is to promote research in all aspects of dentistry for children, including interceptive orthodontics and studies on children and young adults with special needs. The EAPD focuses on the publication and critical evaluation of clinical and basic science research related to children. The EAPD will consider clinical case series reports, followed by the relevant literature review, only where there are new and important findings of interest to Paediatric Dentistry and where details of techniques or treatment carried out and the success of such approaches are given.