Serological evidence of louse-borne relapsing fever in northern Kenya

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease Pub Date : 2024-03-13 DOI:10.1016/j.tmaid.2024.102714

Flavia Reyer , Martyna Olesiuk , Florian Röttgerding , Volker Fingerle , Abdulrahman Adamu , Dan Waithiru , John Njeru , Peter Kraiczy

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引用次数: 0

Abstract

Background

Tick- and louse-borne relapsing fever are highly-neglected, vector-borne diseases caused by diverse Borrelia species. Presently, there are no data available on the endemicity of tick- and louse-borne relapsing fever spirochetes in Kenya. Here, we present data of a retrospective study on the seroprevalence of louse-borne relapsing fever (LBRF) in northern Kenya.

Methods

A novel immunoassay, recently established for the diagnosis of LBRF was utilized to screen 2005 blood samples collected from individuals with fever without a source in Turkana County, Kenya between May 2009 and November 2010 for anti-LBRF antibodies.

Results

Out of the 2005 sera analyzed, 287 samples (14.3 %) were considered anti-LBRF IgG positive. Subsequent analyses revealed that 87 out of 152 sera randomly selected from these 2005 samples were tested positive (57.2 %) for anti-LBRF IgM antibodies. Most of the IgG and IgM positive samples were from individuals living in northern regions of Turkana County.

Conclusion

Our serological finding provides strong evidence for the occurrence of LBRF in Kenya.

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肯尼亚北部虱媒复发热的血清学证据。

背景：蜱虫和虱子传播的复发性热是一种高度被忽视的病媒传播疾病，由多种多样的包柔氏螺旋体引起。目前，还没有关于肯尼亚蜱虫和虱子传播的复发性热螺旋体地方病流行情况的数据。在此，我们介绍一项关于肯尼亚北部虱媒复发性热（LBRF）血清流行率的回顾性研究数据：方法：我们利用最近建立的用于诊断 LBRF 的新型免疫测定方法，对 2009 年至 2010 年间在肯尼亚图尔卡纳县从无发热源的发热患者身上采集的 2005 份血样进行了抗 LBRF 抗体筛查：在分析的 2005 份血清样本中，有 287 份样本（14.3%）被认为是抗 LBRF IgG 阳性。随后的分析显示，从 2005 年的样本中随机抽取的 152 份血清中有 87 份（57.2%）检测出抗 LBRF IgM 抗体呈阳性。大多数 IgG 和 IgM 阳性样本都来自图尔卡纳县北部地区：我们的血清学发现为肯尼亚出现 LBRF 提供了有力的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Travel Medicine and Infectious Disease PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-INFECTIOUS DISEASES

CiteScore

19.40

自引率

1.70%

发文量

211

审稿时长

49 days

期刊介绍： Travel Medicine and Infectious Disease Publication Scope: Publishes original papers, reviews, and consensus papers Primary theme: infectious disease in the context of travel medicine Focus Areas: Epidemiology and surveillance of travel-related illness Prevention and treatment of travel-associated infections Malaria prevention and treatment Travellers' diarrhoea Infections associated with mass gatherings Migration-related infections Vaccines and vaccine-preventable disease Global policy/regulations for disease prevention and control Practical clinical issues for travel and tropical medicine practitioners Coverage: Addresses areas of controversy and debate in travel medicine Aims to inform guidelines and policy pertinent to travel medicine and the prevention of infectious disease Publication Features: Offers a fast peer-review process Provides early online publication of accepted manuscripts Aims to publish cutting-edge papers