Characteristics of Carcinoembryonic Antigen-Related Cell Adhesion Molecules and Their Relationship to Cancer.

IF 5.3 2区医学 Q1 ONCOLOGY

Molecular Cancer Therapeutics Pub Date : 2024-07-02 DOI:10.1158/1535-7163.MCT-23-0461

Ru-Xue Ma, Jian-Rui Wei, Yan-Wei Hu

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引用次数: 0

Abstract

Carcinoembryonic antigen-related cell adhesion molecules (CEACAM), such as carcinoembryonic antigen (CEA) and the oncofetal glycoprotein family, are tumor markers. The CEACAMs consist of 12 different human CEACAMs and 5 different murine CEACAMs. The CEACAM family of proteins participates in multiple biological processes that include the immune response, angiogenesis, and cancer. CEACAMs play a significant role in cancer initiation and development. Increasing evidence suggests that family members may be new cancer biomarkers and targets in that CEACEAMs tend to be aberrantly expressed and therefore may have potential diagnostic and therapeutic importance. This review systematically summarizes the biogenesis, biological properties, and functions of CEACAMs, with a focus on their relationship with cancer and potential clinical application. As our knowledge of the relationships among CEACAMs and cancer increases, and as our understanding of the involved molecular mechanisms improves, new therapeutic strategies will evolve for cancer prevention and treatment of patients with cancer.

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癌胚抗原相关细胞粘附分子的特征及其与癌症的关系。

癌胚抗原相关细胞粘附分子（CEACAMs），如癌胚抗原（CEA）和胎盘糖蛋白家族，是肿瘤标志物。CEACAM 包括 12 种不同的人类 CEACAM 和 5 种不同的鼠类 CEACAM。CEACAM 蛋白家族参与多种生物过程，包括免疫反应、血管生成和癌症。CEACAM 在癌症的诱发和发展过程中发挥着重要作用。越来越多的证据表明，该家族成员可能是新的癌症生物标志物和靶标，因为 CEACEAMs 往往表达异常，因此可能具有潜在的诊断和治疗意义。本综述系统地总结了 CEACAMs 的生物发生、生物特性和功能，重点关注它们与癌症的关系以及潜在的临床应用。随着我们对 CEACAMs 与癌症之间关系的认识不断加深，以及对相关分子机制的理解不断提高，新的治疗策略将在癌症预防和癌症患者治疗方面得到发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cancer Therapeutics 医学-肿瘤学

CiteScore

11.20

自引率

1.80%

发文量

331

审稿时长

3 months

期刊介绍： Molecular Cancer Therapeutics will focus on basic research that has implications for cancer therapeutics in the following areas: Experimental Cancer Therapeutics, Identification of Molecular Targets, Targets for Chemoprevention, New Models, Cancer Chemistry and Drug Discovery, Molecular and Cellular Pharmacology, Molecular Classification of Tumors, and Bioinformatics and Computational Molecular Biology. The journal provides a publication forum for these emerging disciplines that is focused specifically on cancer research. Papers are stringently reviewed and only those that report results of novel, timely, and significant research and meet high standards of scientific merit will be accepted for publication.