Cerebrospinal Fluid Liquid Biopsies in the Evaluation of Adult Gliomas.

IF 4.7 2区医学 Q1 ONCOLOGY

Current Oncology Reports Pub Date : 2024-04-01 Epub Date: 2024-03-15 DOI:10.1007/s11912-024-01517-6

Allison R Valerius, Mason J Webb, Nouran Hammad, Ugur Sener, Rachna Malani

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引用次数: 0

Abstract

Purpose of review: This review aims to discuss recent research regarding the biomolecules explored in liquid biopsies and their potential clinical uses for adult-type diffuse gliomas.

Recent findings: Evaluation of tumor biomolecules via cerebrospinal fluid (CSF) is an emerging technology in neuro-oncology. Studies to date have already identified various circulating tumor DNA, extracellular vesicle, micro-messenger RNA and protein biomarkers of interest. These biomarkers show potential to assist in multiple avenues of central nervous system (CNS) tumor evaluation, including tumor differentiation and diagnosis, treatment selection, response assessment, detection of tumor progression, and prognosis. In addition, CSF liquid biopsies have the potential to better characterize tumor heterogeneity compared to conventional tissue collection and CNS imaging. Current imaging modalities are not sufficient to establish a definitive glioma diagnosis and repeated tissue sampling via conventional biopsy is risky, therefore, there is a great need to improve non-invasive and minimally invasive sampling methods. CSF liquid biopsies represent a promising, minimally invasive adjunct to current approaches which can provide diagnostic and prognostic information as well as aid in response assessment.

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脑脊液液体活检在成人胶质瘤评估中的应用

综述的目的：本综述旨在讨论有关液体活检中探索的生物大分子的最新研究及其在成人型弥漫性胶质瘤中的潜在临床用途：通过脑脊液（CSF）评估肿瘤生物分子是神经肿瘤学领域的一项新兴技术。迄今为止的研究已经确定了各种感兴趣的循环肿瘤 DNA、细胞外囊泡、微信使 RNA 和蛋白质生物标记物。这些生物标记物显示出在中枢神经系统（CNS）肿瘤评估的多个方面提供帮助的潜力，包括肿瘤分化和诊断、治疗选择、反应评估、肿瘤进展检测和预后。此外，与传统的组织采集和中枢神经系统成像相比，CSF 液体活检有可能更好地描述肿瘤的异质性。目前的成像模式不足以确定胶质瘤的明确诊断，而通过传统活检重复采集组织样本又存在风险，因此亟需改进无创和微创采样方法。脑脊液液体活检是目前一种很有前景的微创辅助方法，可提供诊断和预后信息，并有助于评估反应。

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来源期刊

Current Oncology Reports ONCOLOGY-

CiteScore

8.50

自引率

0.00%

发文量

187

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.