The Role of [18F]FDG PET/CT in the Characterization of Thymic Epithelial Tumors at Initial Stage.

IF 2.4 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Cancer Biotherapy and Radiopharmaceuticals Pub Date : 2024-06-01 Epub Date: 2024-03-14 DOI:10.1089/cbr.2023.0192
Caner Civan, Zeynep Gozde Ozkan, Berker Ozkan, Emine Goknur Isik, Eren Erdogdu, Duygu Has Simsek, Salih Duman, Yasemin Sanli, Murat Kara, Serkan Kuyumcu, Alper Toker
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引用次数: 0

Abstract

Purpose: The aim of this study was to evaluate the potential role of [18F]FDG positron emission tomography/computed tomography (PET/CT) in the characterization of thymic epithelial tumors (TETs). Materials and Methods: A total of 73 patients who underwent preoperative [18F]FDG PET/CT were included in this study. Visual total score (VTS), maximum standard uptake values (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and heterogeneity index (HI) parameters were analyzed to investigate the prediction of histopathologic grade and advanced stage. Results: The cohort included 26 patients with low-grade thymoma (LGT), 36 patients with high-grade thymoma (HGT), and 11 patients with thymic carcinoma (TC). Ninety-one percent of TC had VTS >2, whereas 31% of LGT and 75% of HGT had VTS >2. SUVmax, MTV, and TLG were statistically significantly higher in the TC group than in both thymoma and HGT. Using the cutoff value of 7.25 for SUVmax, TC was differentiated from thymomas with 91% sensitivity and 74% specificity. TC had significantly lower HI values than thymomas. HI parameters showed good diagnostic ability to differentiate TC from thymoma and TC from HGT. SUVmax, MTV, and TLG were significantly higher in advanced-stage disease than in early-stage disease. Conclusions: Visual and quantitative parameters can reliably predict both advanced disease and the grade of primary tumor in TETs. Therefore, as a promising metabolic imaging method, [18F]FDG PET/CT makes important contributions to preoperative evaluation in routine clinical practice.

18F]FDG PET/CT 在初期胸腺上皮肿瘤特征描述中的作用
目的:本研究旨在评估[18F]FDG 正电子发射断层扫描/计算机断层扫描(PET/CT)在描述胸腺上皮肿瘤(TET)特征方面的潜在作用。材料与方法:本研究共纳入 73 例术前接受[18F]FDG PET/CT 检查的患者。对视觉总评分(VTS)、最大标准摄取值(SUVmax)、代谢肿瘤体积(MTV)、病变总糖酵解(TLG)和异质性指数(HI)参数进行分析,以研究对组织病理学分级和晚期的预测。结果研究对象包括26名低度胸腺瘤(LGT)患者、36名高级别胸腺瘤(HGT)患者和11名胸腺癌(TC)患者。91%的TC患者VTS>2,而31%的LGT和75%的HGT患者VTS>2。TC组的SUVmax、MTV和TLG在统计学上明显高于胸腺瘤和HGT。SUVmax的临界值为7.25,TC与胸腺瘤的鉴别灵敏度为91%,特异度为74%。TC的HI值明显低于胸腺瘤。HI参数在区分TC和胸腺瘤以及TC和HGT方面显示出良好的诊断能力。晚期疾病的SUVmax、MTV和TLG明显高于早期疾病。结论:视觉和定量参数能可靠地预测 TET 的晚期疾病和原发肿瘤的分级。因此,作为一种有前途的代谢成像方法,[18F]FDG PET/CT 在常规临床实践中为术前评估做出了重要贡献。
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来源期刊
CiteScore
7.80
自引率
2.90%
发文量
87
审稿时长
3 months
期刊介绍: Cancer Biotherapy and Radiopharmaceuticals is the established peer-reviewed journal, with over 25 years of cutting-edge content on innovative therapeutic investigations to ultimately improve cancer management. It is the only journal with the specific focus of cancer biotherapy and is inclusive of monoclonal antibodies, cytokine therapy, cancer gene therapy, cell-based therapies, and other forms of immunotherapies. The Journal includes extensive reporting on advancements in radioimmunotherapy, and the use of radiopharmaceuticals and radiolabeled peptides for the development of new cancer treatments.
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