The Role of Innate and Adaptive Immune System in the Pathogenesis of Schizophrenia.

IF 1.2 4区 医学 Q4 ALLERGY
Marziyeh Soltani, Yousef Mirzaei, Ali Hussein Mer, Mina Mohammad-Rezaei, Zahra Shafaghat, Soheila Fattahi, Fatemeh Azadegan-Dehkordi, Meghdad Abdollahpour-Alitappeh, Nader Bagheri
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Abstract

Schizophrenia is one of the most severely debilitating mental disorders that affects 1.1% of the world's population. The exact cause of the disease is not known, but genetics, environmental factors (such as infectious agents, season and region of birth, exposure to viruses, low birth weight, advanced paternal age, and tobacco), and immune system dysfunction can all contribute to the development of schizophrenia. Recently, the role of the immune system in schizophrenia has received much attention. Both acquired and innate immune systems are involved in the pathogenesis of schizophrenia and facilitate the disease's progression. Almost all cells of the immune system including microglia, B cells, and T cells play an important role in the blood-brain barrier damage, inflammation, and in the progression of this disease. In schizophrenia, the integrity of the blood-brain barrier is reduced and then the immune cells are recruited into the endothelium following an increase in the expression of cell adhesion molecules. The entry of immune cells and cytokines leads to inflammation and antibody production in the brain. Accordingly, the results of this study strengthen the hypothesis that the innate and acquired immune systems are involved in the pathogenesis of schizophrenia.

先天性和适应性免疫系统在精神分裂症发病机制中的作用。
精神分裂症是最严重的精神疾病之一,全世界有 1.1%的人患有精神分裂症。该病的确切病因尚不清楚,但遗传、环境因素(如传染源、出生季节和地区、接触病毒、出生体重过轻、父亲年龄过大和吸烟)以及免疫系统功能紊乱都可能导致精神分裂症的发生。最近,免疫系统在精神分裂症中的作用受到了广泛关注。获得性免疫系统和先天性免疫系统都参与了精神分裂症的发病机制,并促进了疾病的发展。几乎所有的免疫系统细胞,包括小胶质细胞、B 细胞和 T 细胞,都在血脑屏障损伤、炎症和疾病进展中发挥着重要作用。在精神分裂症患者中,血脑屏障的完整性降低,细胞粘附分子的表达增加,免疫细胞被招募到内皮细胞中。免疫细胞和细胞因子的进入导致脑部炎症和抗体的产生。因此,本研究的结果加强了先天性免疫系统和获得性免疫系统参与精神分裂症发病机制的假设。
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来源期刊
CiteScore
2.60
自引率
6.70%
发文量
64
审稿时长
>12 weeks
期刊介绍: The Iranian Journal of Allergy, Asthma and Immunology (IJAAI), an international peer-reviewed scientific and research journal, seeks to publish original papers, selected review articles, case-based reviews, and other articles of special interest related to the fields of asthma, allergy and immunology. The journal is an official publication of the Iranian Society of Asthma and Allergy (ISAA), which is supported by the Immunology, Asthma and Allergy Research Institute (IAARI) and published by Tehran University of Medical Sciences (TUMS). The journal seeks to provide its readers with the highest quality materials published through a process of careful peer reviews and editorial comments. All papers are published in English.
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