Measurement of the Neutrophils Count and Oxidative Burst in Neutrophils of Patients with Sanjad Sakati Syndrome.

IF 1.2 4区 医学 Q4 ALLERGY
Farhad Abolnezhadian, Majid Aminzadeh, Sara Iranparast, Sajad Dehnavi, Fatemeh Dousti, Moosa Sharifat, Hamid Moradzadegan
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Abstract

Sanjad Sakati Syndrome (SSS) is categorized as a neuroendocrine-related disease due to disorders of the nervous and hormonal systems. Since hormonal changes in these patients may affect the nature and function of the immune system. Thus, in this study, cell count and phagocytotic function of neutrophils were evaluated which may be influenced by changes in the hormonal rate and growth factors. In this study, the neutrophil count value and the oxidative burst were evaluated in six patients diagnosed with SSS and six healthy individuals. There was a significant reduction in the neutrophil count observed in SSS patients compared to healthy controls (37.41±7.93 percent vs. 66.5±6.8 percent). However, there was no significant difference in neutrophil oxidative index between patients with SSS and control subjects (172.33±55.08 vs. 217.00±77.38). We concluded that in patients with SSS, the phagocytic activity of neutrophils was not affected by hormonal changes, while the number of neutrophils and neutrophil-to-lymphocyte ratio (NLR) index were decreased.

桑贾德-萨卡提综合征患者中性粒细胞计数和氧化爆发的测定
桑贾德-萨卡蒂综合征(SSS)被归类为神经和激素系统紊乱导致的神经内分泌相关疾病。由于这些患者体内的激素变化可能会影响免疫系统的性质和功能。因此,本研究对中性粒细胞的细胞计数和吞噬功能进行了评估,这些功能可能会受到激素率和生长因子变化的影响。本研究对六名确诊为 SSS 的患者和六名健康人的中性粒细胞计数值和氧化爆发进行了评估。与健康对照组相比,SSS 患者的中性粒细胞数量明显减少(37.41±7.93% vs. 66.5±6.8%)。但是,SSS 患者与对照组之间的中性粒细胞氧化指数(172.33±55.08 vs. 217.00±77.38)没有明显差异。我们的结论是,SSS 患者中性粒细胞的吞噬活性不受激素变化的影响,而中性粒细胞的数量和中性粒细胞与淋巴细胞比值(NLR)指数则有所下降。
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来源期刊
CiteScore
2.60
自引率
6.70%
发文量
64
审稿时长
>12 weeks
期刊介绍: The Iranian Journal of Allergy, Asthma and Immunology (IJAAI), an international peer-reviewed scientific and research journal, seeks to publish original papers, selected review articles, case-based reviews, and other articles of special interest related to the fields of asthma, allergy and immunology. The journal is an official publication of the Iranian Society of Asthma and Allergy (ISAA), which is supported by the Immunology, Asthma and Allergy Research Institute (IAARI) and published by Tehran University of Medical Sciences (TUMS). The journal seeks to provide its readers with the highest quality materials published through a process of careful peer reviews and editorial comments. All papers are published in English.
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