Comparative effectiveness and safety of prasugrel and ticagrelor in patients of acute coronary syndrome undergoing percutaneous transluminal coronary angioplasty: A propensity score-matched analysis

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Indian heart journal Pub Date : 2024-03-01 DOI:10.1016/j.ihj.2024.03.001

Avik Ray , Ahmad Najmi , Gaurav Khandelwal , Ratinder Jhaj , Balakrishnan Sadasivam

引用次数: 0

Abstract

Evidence on comparative effectiveness and safety of prasugrel and ticagrelor post-percutaneous transluminal coronary angioplasty is scarce in Indian population. In a 1:1 propensity score-matched cohort with 71 individuals in each group, the incidence of a composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or coronary revascularization was not significantly different in prasugrel and ticagrelor group (7.04% vs 9.86%; absolute difference, 2.8%; HR, 0.65; 95% CI, 0.21–2.1; p = 0.49). There was no significant difference in bleeding (5.63% vs 9.86%; absolute difference, −4.20%; 95% CI, −13.0%–4.5%) and dyspnea (7.04% vs 12.7%; absolute difference, −5.60%; 95% CI, −15.4%–4.1%).

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普拉格雷和替卡格雷在接受经皮冠状动脉腔内成形术的急性冠状动脉综合征患者中的有效性和安全性比较：倾向评分匹配分析

在印度人群中，有关经皮冠状动脉腔内成形术后普拉格雷和替卡格雷的有效性和安全性比较的证据很少。在1:1倾向得分匹配队列（每组71人）中，普拉格雷组和替卡格雷组心血管死亡、非致死性心肌梗死、非致死性卒中或冠状动脉血运重建的复合发生率无显著差异（7.04% vs 9.86%；绝对差异，2.8%；HR，0.65；95% CI，0.21-2.1；P = 0.49）。出血（5.63% vs 9.86%；绝对差异，-4.20%；95% CI，-13.0%-4.5%）和呼吸困难（7.04% vs 12.7%；绝对差异，-5.60%；95% CI，-15.4%-4.1%）无明显差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian heart journal CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

52 days

期刊介绍： Indian Heart Journal (IHJ) is the official peer-reviewed open access journal of Cardiological Society of India and accepts articles for publication from across the globe. The journal aims to promote high quality research and serve as a platform for dissemination of scientific information in cardiology with particular focus on South Asia. The journal aims to publish cutting edge research in the field of clinical as well as non-clinical cardiology - including cardiovascular medicine and surgery. Some of the topics covered are Heart Failure, Coronary Artery Disease, Hypertension, Interventional Cardiology, Cardiac Surgery, Valvular Heart Disease, Pulmonary Hypertension and Infective Endocarditis. IHJ open access invites original research articles, research briefs, perspective, case reports, case vignette, cardiovascular images, cardiovascular graphics, research letters, correspondence, reader forum, and interesting photographs, for publication. IHJ open access also publishes theme-based special issues and abstracts of papers presented at the annual conference of the Cardiological Society of India.